CAR-T Toxicity Check: From Approval to Practice, Managing Side Effects of CAR-T Therapy

Welcome to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain dive deep into the rapidly evolving world of CAR T cell therapy, a groundbreaking treatment for various hematologic malignancies. Joined by experts Dr. Surbhi Sidana from Stanford University and Dr. Jason Westin from MD Anderson Cancer Center, we explore the mechanism of action of CAR T cells, their side effects, and management strategies.

 

Episode Highlights:

• Understanding CAR T cell therapy and its application in hematologic malignancies and solid tumors.
• Mechanism of action: How CAR T cells are engineered to target cancer cells.
• Acute side effects: Cytokine release syndrome (CRS) and neurotoxicity, including clinical pearls for management.
• Chronic side effects: Monitoring for infections, cytopenias, and the risk of secondary malignancies.
• The importance of bridging therapy and managing tumor burden before CAR T treatment.
• Insights for community oncologists on patient management and communication with CAR T centers.

 

Join us for an informative discussion that emphasizes the importance of recognizing and managing the unique side effects of CAR T therapy to ensure the best outcomes for patients. Don't forget to check out our other episodes for more insights into recent advances in hematology and oncology!

 

Subscribe for more discussions on FDA approvals, treatment algorithms, and conference highlights. We are the Oncology Brothers!

 

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