In this episode of the Epigenetics Podcast, we talked with Francesca Telese from UC San Diego and Jessica Zhou from Cold Spring Harbour about their work on the molecular underpinnings of human addiction.
Francesca Telese worked on neuronal enhancers and their pivotal role in governing gene activity. She sheds light on her remarkable findings concerning the epigenetic signature of neuronal enhancers that are intricately involved in synaptic plasticity.
Jessica Zhou joined Francesca Telese's lab as a PhD student where she worked on elucidating the effects of chronic cannabis use on memory and behavior in mice. She takes us through the fascinating correlation between THC and gene co-expression networks. Francesca and Jessicathen discuss the utilization of genetically diverse outbred rats in their research, along with the crucial exploration of cell type specificity in gene expression studies. They then delve into the long-term changes that occur in the brain after drug exposure and the profound implications for relapse. Additionally, they touch upon the challenges they face in analyzing single-cell data.
References
Zhou, J. L., de Guglielmo, G., Ho, A. J., Kallupi, M., Pokhrel, N., Li, H. R., Chitre, A. S., Munro, D., Mohammadi, P., Carrette, L. L. G., George, O., Palmer, A. A., McVicker, G., & Telese, F. (2023). Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition. Nature neuroscience, https://doi.org/10.1038/s41593-023-01452-y
Wang, J., Telese, F., Tan, Y., Li, W., Jin, C., He, X., Basnet, H., Ma, Q., Merkurjev, D., Zhu, X., Liu, Z., Zhang, J., Ohgi, K., Taylor, H., White, R. R., Tazearslan, C., Suh, Y., Macfarlan, T. S., Pfaff, S. L., & Rosenfeld, M. G. (2015). LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control. Nature neuroscience, 18(9), 1256–1264. https://doi.org/10.1038/nn.4069
Related Episodes
The Role of Histone Dopaminylation and Serotinylation in Neuronal Plasticity (Ian Maze)
Contact
Epigenetics Podcast on X
Epigenetics Podcast on Instagram
Epigenetics Podcast on Mastodon
Epigenetics Podcast on Bluesky
Epigenetics Podcast on Threads
Active Motif on Twitter
Active Motif on LinkedIn
Email: podcast@activemotif.com
H3K4me3, Set-Proteins, Isw1 and their Role in Transcription (Jane Mellor)
The role of DNA Methylation in Epilepsy (Katja Kobow)
MacroH2A Function in Development and Disease (Emily Bernstein)
Spatio-Temporal Alterations in Chromosome Dynamics (Jane Skok)
Chromatin Organization During Development and Disease (Marieke Oudelaar)
Enhancers and Chromatin Remodeling in Mammary Gland Development (Camila dos Santos)
The Role of SMCHD1 in Development and Disease (Marnie Blewitt)
Single-Molecule Imaging of the Epigenome (Efrat Shema)
Heterochromatin Protein 1 and its Influence on the Structure of Chromatin (Serena Sanulli)
The Effects of Early Life Stress on Mammalian Development (Catherine J. Peña)
Targeting COMPASS to Cure Childhood Leukemia (Ali Shilatifard)
Effects of Non-Enzymatic Covalent Histone Modifications on Chromatin (Yael David)
ATAC-Seq, scATAC-Seq and Chromatin Dynamics in Single-Cells (Jason Buenrostro)
Synthetic Chromatin Epigenetics (Karmella Haynes)
Development of Integrative Machine Learning Tools for Neurodegenerative Diseases (Enrico Glaab)
Ultraconserved Enhancers and Enhancer Redundancy (Diane Dickel)
Variants of Core Histones: Modulators of Chromatin Structure and Function (Sandra Hake)
DNA Methylation and Mammalian Development (Déborah Bourc'his)
Chromatin Analysis using Mass Spectrometry (Axel Imhof)
Chromatin Profiling: From ChIP to CUT&RUN, CUT&Tag and CUTAC (Steven Henikoff)
Create your
podcast in
minutes
It is Free
DNA Today: A Genetics Podcast
Museum of the Missing
Strange by Nature Podcast
Sasquatch Chronicles
Hidden Brain