”Got Guts” The Micro Version: Pf Inhibits Inflammation-Induced Epithelial Break-Down

In this episode Marine Mantel of Nantes Université discusses the recently published research in AJP-GI and Liver Physiology titled "Propionibacterium freudenreichii CIRM-BIA 129 mitigates colitis through S layer protein B-dependent epithelial strengthening." 

 

NEW & NOTEWORTHY Propionibacterium freudenreichii reduces dextran sodium sulfate (DSS)-induced intestinal permeability in vivo. P. freudenreichii does not inhibit inflammation but damages linked to inflammation. P. freudenreichii inhibits intestinal epithelial breakdown through S-layer protein B. The protective effects of P. freudenreichii depend on S-layer protein B. Extracellular vesicles from P. freudenreichii CB 129 mimic the protective effect of the probiotic.

 

Article Citation:

Propionibacterium freudenreichii CIRM-BIA 129 mitigates colitis through S layer protein B-dependent epithelial strengthening

Marine Mantel, Tony Durand, Anne Bessard, Ségolène Pernet, Julie Beaudeau, Juliana Guimaraes-Laguna, Marie-Bernadette Maillard, Eric Guédon, Michel Neunlist, Yves Le Loir, Gwénaël Jan, and Malvyne Rolli-Derkinderen

American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:2, G163-G175