Proteostasis in Senescent Endothelial Cells

Do senescent primary human coronary artery endothelial cells have a diminished heat shock response and/or impaired proteostasis? Listen as Editor in Chief Irving H. Zucker (University of Nebraska Medical Center) interviews lead author Aldrin Gomes (University of California Davis) and content expert Cameron McCarthy (University of Toledo) about this novel new study by Hwang et al, which determines that estrogen did not decrease protein aggregation nor improve the heat shock response in senescent vascular endothelial cells. As the current study was performed using all female donor coronary artery endothelial cells, the authors suspect sex differences play a key role in estrogen and heat shock response. How might the regulation of anti-oxidant enzymes and the pro- anti-oxidant transcription factor Nrf-2 play a role in reducing oxidative stress and proteolysis? Does a so-called Mediterranean diet show promise in reducing levels of oxidative stress biomarkers? Listen and learn more.

 

HyunTae V. Hwang, Yun Lin, Michelle N. Rebuffatti, Darlene T. Tran, Lily Lee, Aldrin V. Gomes, Chin-Shang Li, and Anne A. Knowlton Impaired proteostasis in senescent vascular endothelial cells: a perspective on estrogen and oxidative stress in the aging vasculature Am J Physiol Heart Circ Physiol, published February 1, 2019. DOI: 10.1152/ajpheart.00318.2018