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Regeneration of brain stem cells boosted by turmeric compound
Institute of Neuroscience and Medicine (Germany) September 28, 2022
A bioactive compound found in turmeric promotes stem cell proliferation and differentiation in the brain, reveals new research published in the open access journal Stem Cell Research & Therapy. The findings suggest aromatic turmerone could be a future drug candidate for treating neurological disorders, such as stroke and Alzheimer’s disease.
The study looked at the effects of aromatic (ar-) turmerone on endogenous neutral stem cells (NSC), which are stem cells found within adult brains. NSC differentiate into neurons, and play an important role in self-repair and recovery of brain function in neurodegenerative diseases. Previous studies of ar-turmerone have shown that the compound can block activation of microglia cells. When activated, these cells cause neuroinflammation, which is associated with different neurological disorders. However, ar-turmerone’s impact on the brain’s capacity to self-repair was unknown.
Researchers from the Institute of Neuroscience and Medicine in Jülich, Germany, studied the effects of ar-turmerone on NSC proliferation and differentiation both in vitro and in vivo. Rat fetal NSC were cultured and grown in six different concentrations of ar-turmerone over a 72 hour period. At certain concentrations, ar-turmerone was shown to increase NSC proliferation by up to 80%, without having any impact on cell death. The cell differentiation process also accelerated in ar-turmerone-treated cells compared to untreated control cells.
Lead author of the study, Adele Rueger, said: “While several substances have been described to promote stem cell proliferation in the brain, fewer drugs additionally promote the differentiation of stem cells into neurons, which constitutes a major goal in regenerative medicine. Our findings on aromatic turmerone take us one step closer to achieving this goal.”
Ar-turmerone is the lesser-studied of two major bioactive compounds found in turmeric. The other compound is curcumin, which is well known for its anti-inflammatory and neuroprotective properties.
Study finds mind-body practices lower blood sugar levels in people with type 2 diabetesUniversity of Southern California School of Medicine, September 30, 2022
Mind-body practices such as yoga and meditation are increasingly popular tools for promoting health and combating diseases, including type 2 diabetes. Approximately 66% of Americans with type 2 diabetes use mind-body practices and many do so because they believe it helps control their blood sugar. Until now, however, whether mind-practices can reduce blood glucose levels has never been rigorously quantified.
According to new research conducted by a team from the Keck School of Medicine of USC, published in the Journal of Integrative and Complementary Medicine, some mind-body practices can be nearly as effective as commonly prescribed drugs at reducing blood glucose levels in people with type 2 diabetes.
The team analyzed data from randomized controlled trials conducted across the globe between 1993 and 2022. They found 28 trials in which people with type 2 diabetes began a mind-body practice in addition to receiving medication and compared their results with people who only received medication to reduce their blood sugar levels.
This study, the first to analyze a range of mind-body practices including meditation, qigong, yoga and mindfulness-based stress reduction and their effect on blood glucose levels, revealed that all mind-body practices led to significant reductions in blood sugar levels.
Taken as a whole, the mind-body practices averaged a .84% reduction in hemoglobin A1c, a measure of the average blood glucose level for the past 3 months. Yoga, the most-studied modality, provided the largest benefit, about a 1% reduction in hemoglobin A1c. The authors noted that a 1% reduction is particularly notable because metformin, the most prescribed diabetes drug, reduces hemoglobin A1c in people with type 2 diabetes by 1.1% on average.
The research suggests that mind-body practices could be used as a both as a complementary nonpharmacological treatment for people with type 2 diabetes and possibly as a preventive measure as well.
Compound in Celery Found to Destroy 86% of Lung Cancer CellsGuangdong Pharmaceutical University (China), September 28th, 2022Ginger effective for muscle pain relief
University of Georgia, Sep 29, 2022
A new study has suggested that daily doses of raw or heat-treated ginger are effective for relieving muscle pain following strenuous exercise.
Some research has shown that ginger may have anti-inflammatory and analgesic properties similar to nonsteroidal anti-inflammatory drugs. In one study, four to 36 weeks of daily ginger doses (30 to 500 mg.) achieved reductions in knee pain from osteoarthritis.
Researchers from the University of Georgia examined the efficacy of multiple days of ginger doses for relieving experimentally induced muscle pain from 18 eccentric muscle exercises.
For the study, student volunteers were tested on 11 consecutive days while taking ginger supplements. Seventy-four students were divided in three groups given either raw ginger, heated ginger or placebo.
The authors hypothesized that pain ratings after exercise would be lower in the ginger group compared to placebo subjects.
Results from the subjects’ responses data showed that both raw and heat-treated ginger lowered muscle pain intensity after eccentric exercise by 25 and 23 per cent, respectively. Heat treating ginger, therefore, did not increase the analgesic benefit.
Whether ground, instant or decaffeinated, coffee drinking associated with longer lifeBaker Heart and Diabetes Research Institute (Australia), September 28 2022.
Regardless of the type of coffee consumed, people who drink coffee may live longer, as indicated by research findings reported in the European Journal of Preventive Cardiology.
“In this large, observational study, ground, instant and decaffeinated coffee were associated with equivalent reductions in the incidence of cardiovascular disease and death from cardiovascular disease or any cause,” senior author Peter Kistler, PhD, stated.
The study included 449,563 men and women enrolled in the UK Biobank, which recruited UK residents from 2006 to 2010 and collected data concerning dietary intake, including coffee consumed, and other factors. Individuals included in the current investigation did not have cardiovascular disease or heart arrhythmias at the beginning of the study.
During an average follow-up of 12.5 years, 27,809 deaths occurred. Compared with non-coffee drinkers, people who reported drinking ground, instant or decaffeinated coffee had a significantly lower risk of dying from all causes during follow-up. The greatest risk reduction was associated with drinking 2 to 3 cups coffee per day, with ground coffee associated with 27% lower risk compared with no coffee drinking. Drinking any type of coffee was also associated with a reduced chance of developing cardiovascular disease, and 2 to 3 cups was again associated with the most protection. The development of arrhythmias was less among people who consumed ground or instant coffee, but not decaffeinated coffee.
“The beverage contains more than 100 biologically active components,” Dr Kistler remarked. “It is likely that the non-caffeinated compounds were responsible for the positive relationships observed between coffee drinking, cardiovascular disease and survival. Our findings indicate that drinking modest amounts of coffee of all types should not be discouraged but can be enjoyed as a heart healthy behavior.”