What attracted Dr. Sonya MacParland to the world of science was the possibility of making a discovery no one else has ever made. It’s exactly what she went on to do – the award-winning scientist at UHN’s Toronto General Hospital Research Institute developed the world’s first transcriptomic map of the liver, triggering a paradigm shift in liver research and therapy.
On this episode of Behind the Breakthrough, Dr. MacParland takes the listener through the intricacies of the only organ in the human body with the ability to regenerate itself - the liver. She explains how she and her team mapped the thousands of cells within it, and why they felt it was integral to keep the research open-access for scientists around the world to use as a guide. Dr. MacParland also dives into the personal side of her success as a scientist, sharing how she deals with the failures and pressures of her work and the role mentorship plays in a successful career.
“Being able to do science and discover together on a daily basis is a gift,” says Dr. MacParland. “The fact that I'm able to do this and work with brilliant students, brilliant scientists and wonderful patients is just so fulfilling.”
Dr. John Dick on his famous discovery of cancer stem cells, and the puzzle of research
Dr. Mansoor Husain on breakthrough drug for diabetes and heart disease
Dr. Alex Mihailidis on helping us live at home longer
Dr. Ralph DaCosta on a better way to visualize cancer and his serendipitous invention
Dr. Heather Baltzer on pioneering hand trauma treatment.
Dr. Pamela Ohashi on revolutionizing cancer treatment with immunotherapy
Dr. Taufik Valiante invents implantable computer chip designed to stop epileptic seizures
Dr. Stephanie Protze on turning stem cells into pacemaker cells
Dr. Brad Wouters on UHN's COVID-19 research, leadership during the pandemic, and anti-vaxxers
Season 2…coming soon!
Dr. Donald Weaver's lifelong quest to cure Alzheimer's
Using computers to understand cancer, with Dr. Michael Hoffman
Pioneering treatments to get spinal cord injured patients mobile, with Dr. Kristin Musselman
Reversing blindness and the serendipity of science, with Dr. Valerie Wallace
Repairing broken hearts with stem cells, with Dr. Michael Laflamme
Overcoming ‘impostor syndrome’ and helping the elderly live well, with Dr. Jennifer Campos
Meet the cancer code breaker, Dr. Mathieu Lupien
Robotics, rehabilitation therapy and learning from failure, with Dr. Milos Popovic
Challenging the meaning of palliative care, with Dr. Camilla Zimmermann
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