Oxidative Stress and Cutaneous Local Heating in Young Smokers

We know smoking is bad for us, but can endothelial dysfunction in smokers be repaired, or even restored? Listen as Editor in Chief Dr. Irving H. Zucker interviews lead author Christopher Minson (University of Oregon) and expert Lacy Alexander (The Pennsylvania State University) about the work by Minson and colleagues which used the skin as a model for microvascular changes in smokers, which can indicate dysfunction earlier on in the progression of disease than macrocirculatory changes. Is nitric oxide a major player in the skin’s vasodilator response to a local cutaneous heat stressor? Listen now.

Naoto Fujii, Vienna E. Brunt, Christopher Todd Minson Tempol improves cutaneous thermal hyperemia through increasing nitric oxide bioavailability in young smokers Am J Physiol Heart Circ Physiol, published online March 28, 2014. DOI: 10.1152/ajpheart.00886.2013.