Particulate Matter Induced Vascular Insulin Resistance

How are diet-independent insulin resistance and defects in endothelial progenitor cell mobilization altered by particulate matter exposure? Find out by listening to this engaging podcast as Guest Editor Loren Wold (The Ohio State University) interviews lead author Petra Haberzettl (University of Louisville) and content expert Timothy Nurkiewicz (West Virginia University) about the recent study by Haberzettl et al published as part of our Call for Papers on Cardiovascular Responses to Environmental Stress. Haberzettl and co-authors used a mouse model to investigate exposure to fine particulate matter, altered sensitivity of blood vessels, and an inflammatory pathway. What “chicken and egg” problem does NOS uncoupling and oxidative stress pose, related to decreased insulin sensitivity via Akt? Does this work challenge the current literature to look beyond cytokines and interleukin-mediated processes to endothelial progenitor cells in the bone marrow? Listen and learn.

Petra Haberzettl, James P. McCracken, Aruni Bhatnagar, Daniel J. Conklin Insulin sensitizers prevent fine particulate matter-induced vascular insulin resistance and changes in endothelial progenitor cell homeostasis Am J Physiol Heart Circ Physiol, published June 1, 2016. DOI: 10.1152/ajpheart.00369.2015