Bench to bedside transition for pharmacological regulation of NRF2 in non-communicable diseases

Discussing the FRBM issue 'Bench to bedside transition for pharmacological regulation of NRF2 in non-communicable diseases' published in the January 2023 issue of the journal.

Speaker: Prof. Masayuki Yamamoto, Tohoku Medical Megabank Organization, Japan 
Moderator: Prof. Giovanni Mann, King's College London, UK 

Prof. Masayuki Yamamoto is the Professor Director of Tohoku University Medical Megabank, an integrated biobank with two prospective large population cohorts for exploring personalized healthcare and medicine.

He has received numerous international awards such as the Lester Packer Award (2018) from SFRRI, Research Excellence Award from the Federation of Asia and Oceania Biochemists and Molecular Biologists (2021), Kahoku Bunka Association Prize (2021), and Ando-Momofuku Research Excellence Prize (2023).

• [0:29] Introduction of Dr. Yamamoto
• [5:07] Dr. Yamamoto's early career and important collaborations
• [15:49] Collaborating with mentor James Douglas Engle
• [27:07] Projects in a little black notebook
• [31:28] If cellular molecular studies due to phase 2 enzymes or involved in antioxidant enzymes
• [49:15] Similar key NRF2 architecture in human organs and mice
• [54:35] Does intervention of the key 1 NRF2 system contribute in any way to personal healthcare and medicine?
• [56:20] How to treat the brain independent of the heart and adjusting medicine interventions internationally.
• [59:41] A search for an activator or inhibitor of NRF2 pathways
• [1:08:13] Conclusion