This is an exciting time in the acute leukemia field, with advances in both the treatment landscape and the pathology of the disease. This podcast features a recent discussion amongst acute leukemia experts from the International Workshop on Acute Leukemias (iwAL) 2019 conference held in Barcelona, Spain. In this podcast, Noelle Frey, MD , University of Pennsylvania, Philadelphia, PA; Bianca Santomasso, MD, PhD, of the Memorial Sloan Kettering Cancer Center, New York, NY; and Wendy Stock, MD, of the University of Chicago Medicine, Chicago, IL, discuss a vast range of topics, including the improvement of patient outcomes, the use of CAR T-cell therapy and the importance of MRD in prognostics.