New York City and Chicago announced fresh restrictions to curb the spread of coronavirus. Pfizer (+0.8%) and its partner BioNTech (+4%) revealed a 95% success rate at the conclusion of their COVID-19 vaccine trial. Retailer Lowe's shares dipped 8.2% after its earnings missed analysts' expectations. Shares of Target (+2.3%) advanced on soaring sales. Boeing shares fell 3.2%, despite the Federal Aviation Administration lifting its ban on the 737 Max aircraft. The Dow Jones index closed lower by 345 points or 1.2% after rising as much as 147 points at session highs. The S&P 500 index was also down 1.2%. And the Nasdaq index fell by 98 points or 0.8%.
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