Mitochondrial Depolarization and Electrophysiology

What is the relationship between cardiac mitochondrial metabolism and the mitochondrial membrane potential? Listen as Associate Editor Gary Lopaschuk interviews lead author Matthew Sulkin (Washington University), and expert Elaine Wan (Columbia University) about the innovative work by Sulkin and colleagues combining two different optical mapping techniques. What did the authors discover when they looked directly at the mitochondrial membrane potential during ischemia-reperfusion, and how might this inform potential therapies for ventricular arrhythmias? Listen and learn more…

Matthew S. Sulkin, Bas J. Boukens, Megan Tetlow, Sarah R. Gutbrod, Fu Siong Ng, Igor R. Efimov Mitochondrial depolarization and electrophysiological changes during ischemia in the rabbit and human heart Am J Physiol Heart Circ Physiol, published October 15, 2014.
DOI: 10.1152/ajpheart.00437.2014.