The Gary Null Show - 08.19.22

VIDEOS:

Dr. Ryan Cole: Covid Vaccine Side Effects Are Like A Nuclear Bomb (10:00)

We don’t need the CIA – The Chris Hedges Report (10:00)

 

GlyNAC supplementation reverses aging hallmarks in aging humans
Baylor College of Medicine, August 19, 2022

A randomized, double blind human clinical trial conducted by researchers at Baylor College of Medicine reveals that supplementation with GlyNAC—a combination of glycine and N-acetylcysteine—improves many age-associated defects in older humans and powerfully promotes healthy aging. This is relevant because until now, there have been no solutions toward improving many of these age-related declines in people.

Published in The Journals of Gerontology: Series A, the study shows that older humans taking GlyNAC for 16-weeks improved many characteristic defects of aging. This includes oxidative stress, glutathione deficiency and multiple aging hallmarks affecting mitochondrial dysfunction, mitophagy, inflammation, insulin resistance, endothelial dysfunction, genomic damage, stem cell fatigue and cellular senescence. These were associated with improvements in muscle strength, gait speed, exercise capacity, waist circumference and blood pressure.

The improvements in oxidative stress, glutathione levels and mitochondrial function in the muscle tissue of older humans taking GlyNAC were similar to the improvements in organs such as the heart, liver and kidneys of aged mice supplemented with GlyNAC as reported in the researchers’ recent publication. Taken together, the results of these studies show that GlyNAC supplementation can improve these defects in many different organs of the body. “GlyNAC supplementation in aging mice increased their length of life mice by 24%,” said Sekhar. “Gait speed is reported to be associated with survival in older humans. Our randomized clinical trial found a significant improvement in gait speed in older humans supplemented with GlyNAC. This raises the interesting question of whether GlyNAC supplementation could have implications for survival in people.”

Mitochondria generate energy needed for supporting cellular functions. However, the ability of mitochondria to work well declines as we age. How to improve the ability of these failing mitochondria to work is not well understood, and therefore no solutions have been available. Sekhar’s group discovered earlier that supplementing GlyNAC in aged mice corrected malfunctioning mitochondria. However, to definitively determine whether GlyNAC supplementation benefited people, a placebo-controlled randomized clinical trial was required.

After 16-weeks of GlyNAC supplementation, mitochondrial function of older people improve toward levels found in young people. This was accompanied by improvements in multiple additional outcomes as reported in the publication. Analysis of the molecular data from the trial suggests that the GlyNAC supplementation is able to fill cells with younger and more efficient mitochondria. “Collectively these exciting new discoveries hold great promise for improving our mitochondrial and general health as we age,” Sekhar said.

A second vital benefit offered by supplementing GlyNAC is that it also helps protect the body from an important problem called oxidative stress. GlyNAC supplementation corrects glutathione deficiency and lowers oxidative stress in older humans back to youthful levels, thereby solving both problems.

“One of the intriguing questions from this trial is why so many improvements occur toward promoting health. We believe that this is due to the combined effort of three separate components—glycine, cysteine (from NAC) and glutathione, and not just due to glutathione itself. Glycine and cysteine are both very important for cellular health on their own, and GlyNAC provides both. Glycine and cysteine are building blocks to form glutathione, which also has health benefits. We believe that the improvements in this trial and in our previous studies are the result of the combined effects of glycine and NAC and glutathione, and we refer to this combination as the ‘Power of 3,'” said Sekhar.

GlyNAC supplementation improved muscle strength in the upper and lower extremity and a trend toward increased exercise capacity. “These findings could have additional implications for improving the health of older humans, especially in terms of being able to be more physically active,” said Sekhar.

High-fructose corn syrup consumption in adolescence impairs learning and memory

University of Southern California, August 12, 2022

Because most corn in America is genetically modified to kill corn “pests,” no human on Earth should be eating it, especially every day. This is now being proven by scientists who run tests on animals in laboratories and have concluded that high-fructose corn syrup (HFCS) and sucrose can impair an adolescent animal’s ability to learn, and it can impair its ability to remember information. And that brings us to the rat genome.

Research reveals a difference between adult animals that consume HFCS-sweetened beverages and adolescent animals that consume the same. The amounts of HFCS used in the research were very similar to the amounts of GMO sugar found in common soft drinks. The study was conducted over one month. The lead author of the study said it’s no secret that soft drinks can lead to not only metabolic disturbances but interference with the brain’s ability to function normally and remember “critical information” about one’s environment.

Dr. Scott Kanoski from the University of Southern California explained, “The hippocampus is such a critical brain region for memory function. In many ways this region is a canary in the coal mine, as it is particularly sensitive to insult by various environmental factors, including eating foods that are high in saturated fat and processed sugar.”

Music More Effective Than Drugs At Releasing Brain’s Painkillers
McGill University (Montreal), August 11, 2022

400 published scientific papers have proven the old adage that “music is medicine.” Neurochemical benefits of music can improve the body’s immune system, reduce anxiety levels and help regulate mood in ways that drugs have difficulty competing.

“We’ve found compelling evidence that musical interventions can play a health care role in settings ranging from operating rooms to family clinics,” says Prof. Levitin of McGill University’s Psychology Department. “But even more importantly, we were able to document the neurochemical mechanisms by which music has an effect in four domains: management of mood, stress, immunity and as an aid to social bonding.”

Like other pleasurable experiences, there are two components to enjoying music: anticipation of hearing your favourite song, and then actually hearing it. The brain signalling chemical dopamine, which is linked to reward, is involved in both phases. But neuroscientists have wondered for decades whether there was more to it — what gives music its power to induce euphoria?

The brain’s natural opioids could be key. Professor Levitin’s team showed that blocking opioid signals in the brain by giving people a drug called naltrexone reduces the amount of pleasure they report getting from their favourite song. They still enjoy the anticipation of hearing the song just as much, suggesting that, although dopamine is involved, it’s when the opioids kick in that music really starts to affect our minds.

A flood of opioids would also explain music’s effect on our body. Listening to music is known to raise people’s pain thresholds, so much so that in some cases, it can be used to reduce the need for morphine-like painkillers. In their analysis, Levitin’s team surveyed over 400 papers, looking for patterns in the scientific evidence supporting the claim that music can affect brain chemistry in a positive way. They succeeded in isolating four areas where music can help:

Reward, motivation, and pleasure (to help with eating disorders, as an example)
Stress and arousal (to help reduce anxiety)
Immunity (to strengthen the body’s immune system and slow-down age related decline)
Social affiliation (to assist in trust building and social bonding)
The researchers connected these areas with four primary neuro-chemical systems:

Dopamine and opioids
Cortisol (and related hormones)
Serotonin (and related hormones)
Oxytocin

“We know music facilitates active neurochemical processes in a symphony of opioids which pharmaceutical intervention has been unable to match,” said Dr. Francis Chandra commenting on the study.

Calcium & magnesium reduce risk of metabolic syndrome: 9000-strong study

Case Western Reserve University, August 14, 2022

Calcium and magnesium may reduce the risk of metabolic syndrome – but men need above and beyond recommended levels for this effect, say researchers.

The researchers from the Case Western Reserve University in the US used 9,148 adults to test the theory that higher dietary intakes of calcium and magnesium decreased the risk of metabolic syndrome.

Using 24-hour recalls as part of the National Health and Nutrition Examination Study, they found women who met the US recommended dietary allowance (RDA) for both magnesium (310–320 mg per day) and calcium (1000–1200 mg per day) saw the greatest decrease in risk of metabolic syndrome. The European RDA for magnesium is 375 mg and 800 mg for calcium.

Meanwhile, they did not see the same association for men meeting the RDA for magnesium (400–420 mg per day) and calcium (1000–1200 mg per day), individually or in combination. However, when these intakes were increased to over 386 mg for magnesium and over 1224 mg per day for calcium, the odds of metabolic syndrome for the men was lowered.

“The underlying mechanisms driving the differences we and others have observed by sex are not well understood and warrant additional mechanistic studies,” the researchers wrote.

The study measured serum triglyceride, high-density lipoprotein (HDL) cholesterol and glucose levels as markers of the condition

Treadmill exercise shown to improve Parkinson’s symptoms in mice
Rush University Medical Center, August 18, 2022

Regular treadmill exercise helped improve Parkinson’s disease symptoms in mice in a recent study by researchers at RUSH University Medical Center. The results of the study were recently published in the Cell Reports.

“We’re very excited about the results,” said Kalipada Pahan, Ph.D., Floyd A. Davis, MD, Endowed Chair in Neurology and professor of neurological sciences, biochemistry, pharmacology at the RUSH University Medical Center. “Our hope is that we can use this as a jumping off point for furthering our ability to help Parkinson’s patients manage their symptoms.”

In the study, scientists found positive results in using regular treadmill exercise to stop the spread of the α-synuclein protein and reverse biochemical, cellular, and anatomical changes that occur in the brains of mice with Parkinson’s disease in the absence of any drugs. The mice in the trial ran on a treadmill consistently in 30-minute intervals for six days a week, over the course of two months.

The findings are key in the ongoing research of Parkinson’s, but Pahan and his team were quick to note that while treadmill exercise is something that can be easily available and accessible, some patients with Parkinson’s might not be able to run on a treadmill daily.

“Once patients are diagnosed with these neurodegenerative disorders, there are no drugs available for halting the disease progression,” Pahan said. “Understanding how the treadmill helps the brain is important to developing treadmill-associated drugs that can inhibit α-synuclein pathology, protect the brain, and stop the progression of Lewy body diseases.”

30 Minutes of Reading a Day Could Add Years to Your Life

University of Sussex (UK) and Yale University, August 7, 2022

Past studies have shown that reading books can benefit people in a multitude of ways, physically, mentally, and intellectually. Now in a new study, people who read a book for about 30 minutes a day were found to live approximately 2 years longer than those who didn’t read at all.

In previous research, curling up with a good book has been shown to improve people’s social skills by improving their ability to read the thoughts and feelings of others.

Researchers at the University of Sussex in England found that reading was “the most effective way to overcome stress” – even better than listening to music, having a cup of tea, or going for a walk.

Reading has also been proven to be a great way to keep the mind sharp, and may reduce mental decline by 32%, helping to prevent Alzheimer’s disease.

For the new study, researchers from Yale University analyzed data on 3,635 people age 50 and older. The participants were divided into 3 groups – those who didn’t read at all, those who read up to 30 minutes a day, and those who read for longer than 3.5 hours per week.

Those who read the most tended to be women with college educations and high incomes.

The researchers said that book readers appear to have a “significant survival advantage” over people who don’t read books. The study didn’t address whether reading on a Kindle or other tablet device counted, but it did find that book readers in general lived an average of 2 years longer than non-readers.

Specifically, the researchers found that people who read up to 3.5 hours a week were 17% less likely to die over the study’s 12-year follow-up period than participants who read no books. This was after accounting for the participants’ age, race, self-reported health, depression, employment, and marital status.

Compared with those who didn’t read books, those who read for more than 3.5 hours a week were 23% less likely to die overall.