Communicating Change in Your Organization

What if something happens in our culture that totally changes your organization?  If you are non-profit, for profit, medical, academic, or government organization and something disrupts how you operate, what do you do? 

Meet the leader who helped navigate her large organization through 2 major disruptions.... that were 10 years apart.  (Hint - she didn't have to lay off or furlough anyone, either).