Breath Analysis: Diagnostics and Technologies

This episode offers a comprehensive overview of human breath analysis as a non-invasive diagnostic tool. It details the composition of exhaled breath, emphasizing volatile organic compounds (VOCs) and their diverse origins, both endogenous and exogenous. It explores various analytical technologies like mass spectrometry (GC-MS, SIFT-MS), sensor arrays (eNoses), and laser spectroscopy, outlining their principles, capabilities, and limitations. It further discusses the crucial aspects of sample collection, contamination control, and commercial platforms, highlighting the ongoing challenges in clinical validation, regulatory approval, and the pursuit of miniaturization for point-of-care applications, ultimately underscoring the field's potential for future advancements in personalized medicine.