Shear- and side-specific mRNAs and miRNAs in HAVECs

In our latest podcast, we investigate aortic valve disease and potential therapeutic interventions other than valvular replacement. Associate Editor Ivor Benjamin interviews authors Hanjoong Jo and Casey Holliday (Emory University) as well as leading expert Jordan Miller (Mayo Clinic) about the recently published article by Holliday et al, which probes the role of endothelial cells in the aortic valve and explores our understanding of mechanosensitive microRNAs responding to shear stress.

 

Casey J. Holliday, Randall F. Ankeny, Hanjoong Jo, and Robert M. Nerem.Discovery of shear- and side-specific mRNAs and miRNAs in human aortic valvular endothelial cells Am J Physiol Heart Circ Physiol published ahead of print June 24, 2011, doi:10.1152/ajpheart.00117.2011.