O-GlcNAc Signaling During Hypertrophy

Does protein glycosylation drive cardiac hypertrophy? In our latest podcast, Editor in Chief William Stanley talks with senior author Steven P. Jones (University of Louisville) and leading expert John Chatham (University of Alabama at Birmingham) to discuss the work by Facundo et al that explores the role of O-GlcNAc in pathological cardiac hypertrophy through NFAT modification. Listen as they discuss the complexities and importance of O-GlcNAc signaling, and explore the methodological challenges in assessing protein O-GlcNAcylation. Is there a role in heart failure or diabetic cardiomyopathy? Listen in and find out.

Heberty T. Facundo, Robert E. Brainard, Lewis J Watson, Gladys A. Ngoh, Tariq Hamid, Sumanth D. Prabhu, and Steven P. Jones O-GlcNAc Signaling is Essential for NFAT-Mediated Transcriptional Reprogramming During Cardiomyocyte Hypertrophy Am J Physiol Heart Circ Physiol, published ahead of print March 9, 2012, doi: 10.1152/ajpheart.00775.2011.