Thromboxane A2-induced Vasoconstriction in Pregnant Rats

The vascular physiology of pregnancy still provide us with surprising observations. In our latest podcast, Associate Editor Nancy Kanagy interviews author Stella Goulopoulou (Georgia Health Sciences University) and leading expert George Osol (University of Vermont College of Medicine) about the new research published by Goulopoulou and colleagues. This work found that the contractile response to thromboxane in uterine arteries is mediated by a surprisingly unique signal transduction pathway. Will further exploration lead to new therapeutic targets for vascular abnormalities in pregnancy during conditions such as preeclampsia? Listen in and find out.

Styliani Goulopoulou, Johanna L. Hannan, Takayuki Matsumoto, and R. Clinton Webb Pregnancy reduces RhoA/Rho kinase and protein kinase C signaling pathways downstream of thromboxane receptor activation in rat uterine artery Am J Physiol Heart Circ Physiol, published online April 27, 2012, doi:10.1152/ajpheart.00900.2011.