Oxidative Stress and Hemodynamics in Heart Failure

Why are heart failure patients exercise intolerant? Is it due to oxidative stress? In our latest podcast, Editor in Chief William Stanley talks with first author Melissa Witman (University of Utah) about her study that assessed the impact of an “antioxidant cocktail” on central and peripheral hemodynamics during exercise in heart failure patients. Carlos Negrao (University of Sao Paulo) lends his expert opinion in this lively conversation. Listen and learn.

Melissa A. H. Witman, John McDaniel, Anette S. Fjeldstad, Stephen J. Ives, Jia Zhao, Jose N. Nativi, Josef Stehlik, D. Walter Wray, and Russell S. Richardson A Differing Role of Oxidative Stress in the Regulation of Central and Peripheral Hemodynamics during Exercise in Heart Failure Am J Physiol Heart Circ Physiol, published online September 7, 2012, doi: 10.1152/ajpheart.00568.2012.