Endothelin-1 and Exercise

How can we tame the sleeping giant of excess skeletal muscle blood flow during exercise? In our latest podcast we expand our understanding of the role endothelin-1 plays in regulating skeletal muscle blood flow during whole body, as well as targeted, exercise in healthy patients. Consulting Editor David Gutterman leads this interesting conversation with author Walter Wray (University of Utah) and expert Kevin Dellsperger (University of Missouri-Columbia) about the recent work by Barrett-O’Keefe et al. What are the possibilities for targeting the endothelin-1 pathway in disease states? Listen now.

Zachary Barrett-O'Keefe, Stephen J. Ives, Joel Douglas Trinity, Richard Garrett Morgan, Matthew Jordan Rossman, Anthony J. Donato, Sean Runnels, David E. Morgan, Benjamin S. Gmelch, Amber D. Bledsoe, Russell S. Richardson, and D. Walter Wray Taming the "Sleeping Giant": The Role of Endothelin-1 in the Regulation of Skeletal Muscle Blood Flow and Arterial Blood Pressure during Exercise Am J Physiol Heart Circ Physiol, published online October 26, 2012, doi:10.1152/ajpheart.00603.2012.