DPP-IV Inhibitor Improves Survival in Murine Heart Failure

Can diabetes treatments also protect the heart? In our latest podcast we explore the work by Takahashi et al, which examined what a DPP-IV inhibitors will do at the level of the heart. Associate Editor Gary Lopaschuk interviews lead author Masanori Asakura (National Cerebral and Cardiovascular Center, Osaka, Japan) and expert Zam Kassiri (University of Alberta) about this exciting new work which pulls together aspects of metabolism, heart failure, anti-diabetic agents and cardioprotection. Listen and learn more.

Ayako Takahashi, Masanori Asakura, Shin Ito, Kyung-Duk Min, Kazuhiro Shindo, Yi Yan, Yulin Liao, Satoru Yamazaki, Shoji Sanada, Yoshihiro Asano, Hatsue Ishibashi-Ueda, Seiji Takashima, Tetsuo Minamino, Hiroshi Asanuma, Naoki Mochizuki, and Masafumi Kitakaze Dipeptidyl-Peptidase IV Inhibition Improves Pathophysiology of Heart Failure and Increases Survival Rate in Pressure-Overloaded Mice Am J Physiol Heart Circ Physiol, published online March 15, 2013, doi: 10.1152/ajpheart.00454.2012.