PART ONE Metabolism of Ketone Bodies in Health and Disease

How does the gut microbiome impact on myocardial energy substrate metabolism? In part one of our two-part podcast on the Review article by Cotter et al, Associate Editor Christine Des Rosiers interviews lead author Peter Crawford (Washington University in St. Louis) and renowned metabolism expert Heinrich Taegtmeyer (University of Texas Medical School). Building on Crawford and colleagues' seminal work published in 2009 on ketone body metabolism using a unique experimental mouse model, which is germ free, we discuss the broad topic of integrated intermediary metabolism. What is the link between the gut microbiome, ketone body metabolism and cardiac physiology? Listen and learn.

David G. Cotter, Rebecca C. Schugar, and Peter A. Crawford Ketone body metabolism and cardiovascular disease Am J Physiol Heart Circ Physiol, published online February 8, 2013, doi: 10.1152/ajpheart.00646.2012.