Mitochondrial Uncoupling and Cardioprotection

What do we know about the relationship between uncoupling proteins (UCP) and myocardial energetics, as well as UCP and ROS production? This podcast explores these topics and more in Associate Editor Gary Lopaschuk’s interview with lead author Cevher Ozcan (University at Buffalo) and expert Hossein Ardehali (Northwestern University) on the work by Ozcan and her colleagues. What is the role of UCP3 in ischemia reperfusion injury, arrhythmia, and preconditioning? What human diseases implicate mutations in UCP3 and other uncoupling proteins in their pathology? Listen to learn more.

Cevher Ozcan, Monica Palmeri, Tamas L. Horvath, Kerry S. Russell, and Raymond R. Russell III Role of uncoupling protein 3 in ischemia-reperfusion injury, arrhythmias, and preconditioning Am J Physiol Heart Circ Physiol, published online March 1, 2013, doi: 10.1152/ajpheart.00592.2012.