NOX4 is Located in Neuron Mitochondria

What is the source of free radicals in neurons? While it is well established that angiotensin II plays an important role in the central regulation of cardiac function, investigators have long sought to better understand the sources of reactive oxygen species in stimulated neurons. In this podcast Consulting Editor Dr. Zoltan Ungvari interviews author Adam Case (University of Nebraska Medical Center) and expert Sergey Dikalov (Vanderbilt University Medical Center) about the latest work by Case et al. Using innovative methods, and both in vitro and in vivo models, Case and co-authors have shown that NOX4 contributes to mitochondrial oxidative stress in neurons. Could NOX4 become a potential therapeutic target via peptide inhibitors for the treatment of hypertension? Tune in and find out.

Adam J. Case, Shumin Li, Urmi Basu, Jun Tian, and Matthew C. Zimmerman Mitochondrial-localized NADPH oxidase 4 is a source of superoxide in angiotensin II-stimulated neurons Am J Physiol Heart Circ Physiol, published online April 26, 2013, doi: 10.1152/ajpheart.00974.2012.