Cardiac Overexpression of Mena Exacerbates Heart Failure in Mice

What is Mena? In this podcast we explore the innovative new work by Belmonte et al on the overexpression of Mammalian homologue of drosophila enabled (Mena) and its exacerbating effects on heart failure secondary to pressure overload. Listen as Associate Editor Ronglih Liao interviews senior author Burns Blaxall (Cincinnati Children's Hospital Medical Center) and leading expert in myocardial and cellular signaling Walter Koch (Temple University School of Medicine) about this intriguing work by Blaxall and colleagues, which explores the complexities of Mena in cellular regulation. How was Mena discovered? Does it play a role in coronary artery disease? Listen and find out.

Stephen L. Belmonte , Rashmi Ram , Deanne M. Mickelsen , Frank B. Gertler , Burns C. Blaxall Cardiac Overexpression of Mammalian enabled (Mena) Exacerbates Heart Failure in Mice Am J Physiol Heart Circ Physiol, published online July 5, 2013, DOI: 10.1152/ajpheart.00342.2013.