Late Sodium Current Inhibition Slows the Progression to Heart Failure

Can early inhibition of the late sodium current slow hypertension-induced t-tubule disruption and calcium cycling defects that lead to heart failure? Join Editor in Chief William C. Stanley as he explores the innovative work by Aistrup et al with senior author J. Andrew Wasserstrom (Northwestern University Feinberg School of Medicine) and leading expert Guy Salama (University of Pittsburgh). Listen as they discuss the effects of chronic treatment with ranolazine on T-tube disruption and the development of heart failure.

Gary L. Aistrup, Deepak K. Gupta, James E. Kelly, Matthew J. O'Toole, Amanda Nahhas, Nimi Chirayil, Sol Misener, Lauren Beussink, Neha Singh, Jason Ng, Mahendra Reddy, Thitipong Mongkolrattanothai, Nesrine El-Bizri, Sridharan Rajamani, John C. Shryock, Luiz Belardinelli, Sanjiv J. Shah, J. Andrew Wasserstrom Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat Am J Physiol Heart Circ Physiol, published online July 19, 2013, doi: 10.1152/ajpheart.00401.2013.