Identification of factors driving DNA methylation variation

In this podcast Dr. Giulia Protti and Prof. Matteo Pellegrini of the University of California discuss the recently published manuscript titled “The methylome of buccal epithelial cells is influenced by age, sex, and physiological properties”. The authors have developed a quantitative model to assess how the human methylome is associated with several factors and to identify the genomic loci significantly impacted by each trait. In this research they have reported novel health-related factors driving DNA methylation patterns and new site-specific regulations that further elucidate methylome dynamics. The study contributes to a better understanding of the plasticity of the human methylome and unveils novel physiological traits with a potential role in future medical epigenomic investigations.

 

Article Citation:

The methylome of buccal epithelial cells is influenced by age, sex, and physiological properties

Giulia Protti, Liudmilla Rubbi, Tarik Gören, Ramazan Sabirli, Serkan Civlan, Özgür Kurt, İbrahim Türkçüer, Aylin Köseler, and Matteo Pellegrini

Physiological Genomics