Currently, five chimeric antigen receptor T-cell (CAR-T) therapies are approved for the treatment of hematological malignancies including acute lymphoblastic leukemia, B-cell lymphoma, non-Hodgkin lymphoma and multiple myeloma. Despite reporting high response rates, the use of CAR-T therapy is associated with a number of practical challenges, including treatment-related adverse events such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), as well as high costs and manufacturing difficulties. It is thus crucial to reduce the incidence and optimize the management of toxicities through careful patient selection and monitoring. CAR-T therapy is also being explored as a treatment option for chronic lymphocytic leukemia (CLL), where attempts with CAR-T have been unsuccessful due to CLL-induced T-cell dysfunction, a process that is currently not well understood.
In this podcast, Arnon Nagler, MD, MSc, of the Chaim Sheba Medical Center, Tel-Hashomer, Israel, Anna Sureda, MD, PhD, of the Catalan Institute of Oncology, Barcelona, Spain, Christian Chabannon, MD, PhD, of the Institut Paoli Calmettes, Marseille, France, and Arnon Kater, MD, PhD, of the University of Amsterdam, Amsterdam, Netherlands, discuss key considerations for the use of CAR-T therapy in clinical practice, as presented at the 4th Annual Meeting of the International Academy for Clinical Hematology (IACH) 2021.
iwNHL 2023 Session II: The evolving treatment landscape in mantle cell lymphoma
iwNHL 2023 Session I: Updates on the biology and treatment of T-cell lymphoma
iwAL 2023 Session IV: transplantation and immunotherapies in AML: improving patient outcomes
Classifying frailty and approaching elderly patients with lymphoma
Updates on the diagnosis, risk stratification and treatment of lower-risk MDS
iwAL 2023 Session III: The relevance of TP53 mutation in AML
iwAL 2023 Session II: Novel treatments in AML: FLT3 inhibitors, combinations, and more
iwAL 2023 Session I: Clonal hematopoiesis in AML, early detection and potential therapeutics
Applications of MRD in multiple myeloma: using MRD to guide treatment decisions
Exploring and comparing the curative potential of CAR-T therapy & bispecific antibodies in R/R DLBCL
Pre-MDS states: improving prognosis, novel therapeutic approaches, and challenges with distinguishing these conditions
Accelerated-phase MPNs: mutational landscape, challenges, and novel treatment strategies being explored
Determining the optimal sequencing of bispecifics and CAR-T cells in multiple myeloma
Overcoming barriers to CAR-T therapy: improving access and cost
The importance of addressing quality of life and improving symptom management in MPNs
Updates in the treatment and management of amyloidosis and the importance of the multidisciplinary team
Hemophilia: the current standard of care and the value of novel gene therapies
CLL highlights at EHA 2023: latest advances with the use of BTK inhibitors
Myeloma highlights at EHA 2023: CARTITUDE-4 & CARTITUDE-1 updates & the use of MRD in clinical practice
Lymphoma highlights at EHA 2023: sequencing bispecifics & CAR-T cells, bridging therapy & toxicity management
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