From Music Industry Powerhouse to Patient Advocate: Mathew Knowles on Men’s Health | EP 74

2025-09-29

What happens when a music executive’s precision meets a life-changing diagnosis? In this candid episode of All Talk Oncology, Kenny Perkins sits down with Mathew Knowles—music executive, author of The DNA of Achievers, and male breast cancer survivor. A tiny sign on a white T-shirt (nipple discharge) led Mathew to insist on a mammogram, a Stage 1A diagnosis, surgery, and the discovery of a BRCA2 variant. Drawing on his 20-year background in medical imaging, he breaks down early detection, building a winning care team, and why he now lives by quarterly labs, therapy, movement, and joy. From COVID-era anxiety to lau...

What happens when a music executive’s precision meets a life-changing diagnosis?
In this candid episode of All Talk Oncology, Kenny Perkins sits down with Mathew Knowles—music executive, author of The DNA of Achievers, and male breast cancer survivor. A tiny sign on a white T-shirt (nipple discharge) led Mathew to insist on a mammogram, a Stage 1A diagnosis, surgery, and the discovery of a BRCA2 variant. Drawing on his 20-year background in medical imaging, he breaks down early detection, building a winning care team, and why he now lives by quarterly labs, therapy, movement, and joy. From COVID-era anxiety to laughter-filled nights with his wife, Mathew shares the mindset shifts and habits that helped him rebuild a life he loves—one mindful walk and measured plate at a time.

Key Topics Discussed

Men get breast cancer: the overlooked red flags (nipple discharge) and why Mathew demanded a mammogram
BRCA2 explained: risk implications for men (melanoma, pancreatic, prostate, male breast cancer) and for women (breast, gynecologic)
Diagnosed at Stage 1A: survival odds, surgery, and five years on Tamoxifen
From isolation to a care team: oncologist, therapist, spiritual support—and why isolation increases risk
COVID anxiety & mental health: therapy to confront fear of dying and regain balance
Diet, weight loss (~40 lbs), and daily 2-mile brisk walks—“cancer loves obesity”
Portion control and practical nutrition: measuring plates, lighter foods, consistent habits
Quarterly labs for peace of mind (not just annual checkups); self-advocacy with your clinicians
“Look out the window”: stillness, nature, laughter, and marriage strengthened through survivorship
Family history & genetics: why genetic testing + knowing your lineage should start early