GI Vagus and Hypertension

In this episode, authors Elliott W. Dirr (University of Toledo), Christopher J. Martyniuk (University of Florida), Kevin J. Otto (University of Florida), and Jasenka Zubcevic (University of Toledo) discuss their recently published paper titled “Subdiaphragmatic vagal nerve stimulation attenuates the development of hypertension and alters nucleus of the solitary tract transcriptional networks in the spontaneously hypertensive rat.”

 

NEW & NOTEWORTHY

Elliott W. Dirr et al. show that stimulation of the ventral subdiaphragmatic vagal nerve branch may be a promising potential approach to treating hypertension. The data are especially encouraging given that rodents received only 30 min per day of intermittent stimulation therapy and in view of the potential of long-term blood pressure effects that are not stimulus-locked.

 

Article Citation:

Subdiaphragmatic vagal nerve stimulation attenuates the development of hypertension and alters nucleus of the solitary tract transcriptional networks in the spontaneously hypertensive rat

Elliott W. Dirr, Ladan G. Jiracek, David M. Baekey, Christopher J. Martyniuk, Kevin J. Otto, and Jasenka Zubcevic

Physiological Genomics 2023 55:12, 606-617