This episode highlights key takeaways for the use of tocilizumab, remdesivir, monoclonal antibodies, and other therapeutics in patients with COVID-19 from the National Institutes of Health, European Respiratory Society, Infectious Diseases Society of America, and Surviving Sepsis Campaign COVID-19 guidelines. (Originally recorded March 11, 2021) Moderator: Casey Cable, MD, MSc. Panelists: Barbara Jones, MD, MSc, and Stefano Aliberti, MD. For more tools to help in the fight against COVID-19, visit CHEST’s COVID-19 Resource Center at chestnet.org/COVID19.