The Gary Null Show - 08.12.21

Astragalus polysaccharides induced programmed cell death in lung cancer tumor cells

Xi’an Jiaotong University (China), August 8, 2021

According to news reporting out of Xi’an, People’s Republic of China, research stated, “To investigate the mechanism of astragalus polysaccharides (PAS) in including the apoptosis of lung cancer tumor cells regulating the factor kappa B (NF-kappa b) and mitogen-activated protein kinase (MAPK) signaling pathways and the expression of apoptosis-related proteins. Of he 45 specific-pathogen (SPF) mice, 9 were selected as the blank control group (0.3 mL normal saline, 1d/time), and the remaining 36 were modeled as tumor-bearing mice.”

Our news journalists obtained a quote from the research from Xi’an Jiaotong University, “After successful modeling, tumor-bearing mice were randomly divided into the model control group (0.3 mL normalsaline, 1d/time), APS low-dose (50 mg/kg APS), APS medium-dose group (100 mg/kg APS), and APS high-dose (200 mg/kg APS). Each group was given continues medication for 20 days. The mRNA and caspase-1 were compered. The mRNA and protein expressions of NF-kappa B p53, and p38 in the model group were significantly higher than those in the control group (P 0.05). The expressions if Bcl-2 and FasL in the model group were significantly higher than those in the blank control group, while the expressions of BAX and capase-9 were significantly lower than those in the blank control group (P