This episode of the VJHemOnc podcast focuses on the treatment of elderly or unfit patients with acute myeloid leukemia (AML). Featuring experts Farhad Ravandi, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Gail Roboz, MD, Weill Cornell Medicine, New York City, NY, Marina Konopleva, MD, PhD, Albert Einstein College of Medicine, New York City, NY, Joshua Zeidner, MD, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, Nelli Bejanyan, MD, Moffitt Cancer Center, Tampa, FL, Parastoo Dahi, MD, MS, Memorial Sloan Kettering, New York City, NY, and Andrius Žučenka, MD, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania. They discuss the current standard of care in the frontline setting, considerations for transplant eligibility, and future approaches being explored, such as triplet combinations including targeted agents.