Development of a NRF2 Knockout Rat

How can we develop a deeper understanding of the regulation and activation of NRF2 in order to target therapies that depend on the inhibition of oxidative stress in a variety of disease states? Our latest podcast seeks an answer to this and more. Listen as Editor in Chief Irving H. Zucker (University of Nebraska Medical Center) interviews lead author Julian Lombard (Medical College of Wisconsin) and content expert Junie Paula Warrington (University of Mississippi Medical Center) about the innovative work by Priestley et al. Lombard and colleagues developed a NRF2 knockout rat to investigate the role of NRF2 in microvascular regulation in the context of a high-salt diet. What are the implications for the pathogenesis of hypertension? And how to “just right” levels of angiotensin 2 play a part in maintaining the NRF2 vs. oxidant stress balance? Listen and find out.

Jessica R. C. Priestley, Katie E. Kautenburg, Marc C. Casati, Bradley T. Endres, Aron M. Geurts, Julian H. Lombard The NRF2 knockout rat: a new animal model to study endothelial dysfunction, oxidant stress, and microvascular rarefaction Am J Physiol Heart Circ Physiol, published February 15, 2016. DOI: 10.1152/ajpheart.00586.2015.