This episode examines the potential for a significant exodus of scientists from the United States, influenced by policy changes proposed in Project 2025 and implemented by the Trump administration in 2025. This analysis details "push" factors such as reduced research funding, shifts in scientific integrity standards, stricter immigration policies impacting foreign talent, and radical restructuring of federal scientific agencies. These domestic pressures are compounded by "pull" factors, including proactive recruitment efforts and attractive opportunities offered by other scientifically advanced nations, particularly in Europe. The episode highlights early indicators of this trend, such as survey data showing scientists considering leaving and a decline in international applications to U.S. research centers. Drawing on historical precedents of scientific migrations, the analysis projects potential timelines for a "massive exodus," emphasizing that its scale and speed depend on the rapid, comprehensive, and perceived irreversible implementation of these policies.