HIF1 Regulates miR-29c and SERCA2

How does HIF1 regulate microRNAs in the heart? This is the question we explore in our latest podcast. Listen as Associate Editor Junichi Sadoshima (Rutgers New Jersey Medical School) interviews authors Ralph Shohet and Allison Williams (both of University of Hawaii), along with content expert Asa Gustafsson (University of California-San Diego), about the intriguing new work by Williams et al. It is known that miR-29c is a critical mediator of HIF1 for downregulation of SERCA2, which is commonly seen in heart failure. Using a tetracycline-inducible transgenic mouse model with an oxygen-stable form of HIF, the authors observed deeper levels of HIF action in the heart. What consequences of stable HIF1 activation did the authors uncover? How closely does isolated HIF expression mimic authentic ischemia? Listen and find out.

 

Allison Lesher Williams, Chad B. Walton, Abigail Avelar, and Ralph Victor Shohet HIF-1 regulation of miR-29c impairs SERCA2 expression and cardiac contractility Am J Physiol Heart Circ Physiol, published February 20, 2019. DOI: 10.1152/ajpheart.00617.2018