Less screen time and more green time are associated with better psychological outcomes among children and adolescents, according to a study published September 2 in the open-access journal PLOS ONE by Tassia Oswald of the University of Adelaide, and colleagues.
The prevalence of mental illness among children and adolescents is increasing globally. Technological developments in recent decades have increased young people's engagement with screen-based technologies (screen time), and a reduction in young people's contact with nature (green time) has been observed concurrently. This combination of high screen time and low green time may affect mental health and well-being. But research investigating the psychological impacts of screen time or green time typically considers each factor in isolation and fails to delineate the reciprocal effects of high technology use and low contact with nature on mental health and cognitive outcomes. To address this question, Oswald and colleagues analyzed the findings of 186 studies to collate evidence assessing associations between screen time, green time, and psychological outcomes (including mental health, cognitive functioning, and academic achievement) for children and adolescents.
In general, high levels of screen time appeared to be associated with unfavorable psychological outcomes, while green time appeared to be associated with favorable psychological outcomes. Young people from low socioeconomic backgrounds were underrepresented in the literature overall and may be disproportionately affected by high screen time and low green time, making this a priority group for future research. However, additional longitudinal studies and RCTs are needed to determine whether decreasing screen time and increasing green time would improve psychological outcomes. According to the authors, preliminary evidence suggests that green time could potentially buffer the consequences of high screen time, meaning nature may be an under-utilized public health resource to promote youth psychological well-being in a high-tech era. Investment in more rigorous research is needed to explore this.
Oswald adds: "This systematic scoping review highlights that nature may currently be an under-utilised public health resource, which could potentially function as an upstream preventative and psychological well-being promotion intervention for children and adolescents in a high-tech era. However, robust evidence is needed to guide policies and recommendations around appropriate screen time and green time at critical life stages, to ultimately ensure optimal psychological well-being for young people."
Ginseng gintonin, aging societies and geriatric brain diseases
Konkuk University (South Korea), September 4, 2020
According to news reporting out of Seoul, South Korea, research stated, “A dramatic increase in aging populations and low birth rates rapidly drive aging societies and increase aging-associated neurodegenerative diseases. However, functional food or medicinal formulations to prevent geriatric brain disorders are not readily available. Gintonin is a candidate, since ginseng has long-been consumed as a rejuvenating agent.”
Our news journalists obtained a quote from the research from Konkuk University, “However, the underlying molecular mechanisms and the components of ginseng that are responsible for brain rejuvenation and human longevity are unknown. Accumulating evidence shows that gintonin is a candidate for the anti-aging ingredient of ginseng, especially in brain senescence. Gintonin, a glycolipoprotein complex, contains three lipid-derived G protein-coupled receptor ligands: lysophosphatidic acids (LPAs), lysophosphatidylinositols (LPIs), and linoleic acid (LA). LPA, LPI, and LA act on six LPA receptor subtypes, GPR55, and GPR40, respectively. These G protein-coupled receptors are distributed within the nervous and non-nervous systems of the human body. Gintonin-enriched fraction (GEF) exhibits anti-brain senescence and effects against disorders such as Alzheimer’s disease (AD), Huntington’s disease (HD), and Parkinson’s disease (PD). Oral administration of gintonin in animal models of d-galactose-induced brain aging, AD, HD, and PD restored cognitive and motor functions. The underlying molecular mechanisms of gintonin-mediated anti-brain aging and anti-neurodegenerative diseases include neurogenesis, autophagy stimulation, anti-apoptosis, anti-oxidative stress, and anti-inflammatory activities. This review describes the characteristics of gintonin and GEF, and how gintonin exerts its effects on brain aging and brain associated-neurodegenerative diseases.”
According to the news editors, the research concluded: “Finally, we describe how GEF can be applied to improve the quality of life of senior citizens in aging societies.”
University of California Berkeley, September 6, 2020
What would you do if you knew how long you had until Alzheimer's disease set in? Don't despair. New research from the University of California, Berkeley, suggests one defense against this virulent form of dementia -- for which no treatment currently exists -- is deep, restorative sleep, and plenty of it.
UC Berkeley neuroscientists Matthew Walker and Joseph Winer have found a way to estimate, with some degree of accuracy, a time frame for when Alzheimer's is most likely to strike in a person's lifetime.
"We have found that the sleep you're having right now is almost like a crystal ball telling you when and how fast Alzheimer's pathology will develop in your brain," said Walker, a UC Berkeley professor of psychology and neuroscience and senior author of the paper published today, Sept. 3, in the journal Current Biology.
"The silver lining here is that there's something we can do about it," he added. "The brain washes itself during deep sleep, and so there may be the chance to turn back the clock by getting more sleep earlier in life."
Walker and fellow researchers matched the overnight sleep quality of 32 healthy older adults against the buildup in their brains of the toxic plaque known as beta-amyloid, a key player in the onset and progression of Alzheimer's, which destroys memory pathways and other brain functions and afflicts more than 40 million people worldwide.
Their findings show that the study participants who started out experiencing more fragmented sleep and less non-rapid eye movement (non-REM) slow-wave sleep were most likely to show an increase in beta-amyloid over the course of the study.
Although all participants remained healthy throughout the study period, the trajectory of their beta-amyloid growth correlated with baseline sleep quality. The researchers were able to forecast the increase in beta-amyloid plaques, which are thought to mark the beginning of Alzheimer's.
"Rather than waiting for someone to develop dementia many years down the road, we are able to assess how sleep quality predicts changes in beta-amyloid plaques across multiple timepoints. In doing so, we can measure how quickly this toxic protein accumulates in the brain over time, which can indicate the beginning of Alzheimer's disease," said Winer, the study's lead author and a Ph.D. student in Walker's Center for Human Sleep Science at UC Berkeley.
In addition to predicting the time it is likely to take for the onset of Alzheimer's, the results reinforce the link between poor sleep and the disease, which is particularly critical in the face of a tsunami of aging baby boomers on the horizon.
While previous studies have found that sleep cleanses the brain of beta-amyloid deposits, these new findings identify deep non-REM slow-wave sleep as the target of intervention against cognitive decline.
And though genetic testing can predict one's inherent susceptibility to Alzheimer's, and blood tests offer a diagnostic tool, neither offers the potential for a lifestyle therapeutic intervention that sleep does, the researchers point out.
"If deep, restorative sleep can slow down this disease, we should be making it a major priority," Winer said. "And if physicians know about this connection, they can ask their older patients about their sleep quality and suggest sleep as a prevention strategy."
The 32 healthy participants in their 60s, 70s and 80s who are enrolled in the sleep study are part of the Berkeley Aging Cohort Study headed by UC Berkeley public health professor William Jagust, also a co-author on this latest study. The study of healthy aging was launched in 2005 with a grant from the National Institutes of Health.
For the experiment, each participant spent an eight-hour night of sleep in Walker's lab while undergoing polysomnography, a battery of tests that record brain waves, heart rate, blood-oxygen levels and other physiological measures of sleep quality.
Over the course of the multi-year study, the researchers periodically tracked the growth rate of the beta-amyloid protein in the participants' brains using positron emission tomography, or PET scans, and compared the individuals' beta-amyloid levels to their sleep profiles.
Researchers focused on the brain activity present during deep slow-wave sleep. They also assessed the study participants' sleep efficiency, which is defined as actual time spent asleep, as opposed to lying sleepless in bed.
The results supported their hypothesis that sleep quality is a biomarker and predictor of disease down the road.
"We know there's a connection between people's sleep quality and what's going on in the brain, in terms of Alzheimer's disease. But what hasn't been tested before is whether your sleep right now predicts what's going to happen to you years later," Winer said. "And that's the question we had."
And they got their answer: "Measuring sleep effectively helps us travel into the future and estimate where your amyloid buildup will be," Walker said.
As for next steps, Walker and Winer are looking at how they can take the study participants who are at high risk of contracting Alzheimer's and implement methods that might boost the quality of their sleep.
"Our hope is that if we intervene, then in three or four years the buildup is no longer where we thought it would be because we improved their sleep," Winer said.
"Indeed, if we can bend the arrow of Alzheimer's risk downward by improving sleep, it would be a significant and hopeful advance," Walker concluded.
Link between positive emotions and health depends on culture
University of Wisconsin, September 8, 2020
Positive emotions are often seen as critical aspects of healthy living, but new researchsuggests that the link between emotion and health outcomes may vary by cultural context. The findings, published in Psychological Science, a journal of the Association for Psychological Science, show that experiencing positive emotions is linked with better cardiovascular health in the US but not in Japan.
"Our key finding is that positive emotions predict blood-lipid profiles differently across cultures," says psychological scientist Jiah Yoo of the University of Wisconsin-Madison. "American adults who experience high levels of positive emotions, such as feeling 'cheerful' and 'extremely happy', are more likely to have healthy blood-lipid profiles, even after accounting for other factors such as age, gender, socioeconomic status, and chronic conditions. However, this was not true for Japanese adults."
"Our findings underscore the importance of cultural context for understanding links between emotion and health, something that has been largely ignored in the literature," Yoo adds. "Although some studies have examined cultural differences in links between positive emotions and healthy functioning, this work is novel in that it includes biological measures of health and large representative samples from both countries."
The fact that positive emotions are conceived of and valued differently across cultures led Yoo and colleagues to wonder whether the health benefits observed in tandem with positive emotions might be specific to Western populations.
"In American cultures, experiencing positive emotions is seen as desirable and is even encouraged via socialization. But in East Asian cultures, people commonly view positive emotions as having dark sides - they are fleeting, may attract unnecessary attention from others, and can be a distraction from focusing on important tasks," says Yoo.
The researchers designed a cross-cultural comparison, examining data from two large representative studies of adults: Midlife in the United States and Midlife in Japan, both funded by the National Institute on Aging. Data included participants' ratings of how frequently they felt 10 different positive emotions in the previous 30 days and measures of blood lipids, which provided objective data on participants' heart health.
"Because of the global prevalence of coronary artery disease, blood lipids are considered important indices of biological health in many Western and East Asian countries," Yoo explains.
As expected, the data indicated that experiencing frequent positive emotions was associated with healthy lipid profiles for American participants. But there was no evidence of such a link for Japanese participants.
The differences may be due, in part, to the relationships between positive emotions and BMI in each culture. Higher positive emotions were linked with lower BMI and, in turn, healthier lipid profiles among American participants, but not among Japanese participants.
"By demonstrating that the cultural variation in the connection between emotional well-being and physical well-being, our research has wide-ranging relevance among those who seek to promote well-being in the communities and the workplace, including clinicians, executives, and policy makers," Yoo concludes.
In future work, the researchers will examine longitudinal data to determine whether the evidence suggests a direct causal link between emotions and health. They also hope to identify emotional profiles that may be more relevant or important to health outcomes in East Asian cultures.
Experimental research suggests co-administration of Panax ginseng and Brassica oleracea plants (kale, broccoli, cabbage, etc) may help protect against osteoporosis
Inha University School of Medicine (South Korea), September 4, 2020
According to news reporting out of Incheon, South Korea, research stated, “Postmenopausal osteoporosis is a common disorder resulting from increased osteoclastic activity.”
The news reporters obtained a quote from the research from Inha University School of Medicine: “To determine the effect of * * Panax ginseng* * on postmenopausal osteoporosis, ovariectomized (OVX) mice were treated with 500 mg/kg/day * * P. ginseng* * extract (Pg) alone or in combination with hot water extract of * * Brassica oleracea* * (Bo) daily for 10 weeks, and the effect of the treatments on OVX-induced bone loss was examined. Bone weight, bone mineral density (BMD), osteoclast (OC) formation, OC marker expression, and biochemical parameters in blood were determined. OVX significantly increased body weight and decreased bone weight compared with those in the Sham group (* * p* * < 0.01). Pg or Bo alone did not affect OVX-induced bone loss, but a combination of Pg and Bo (Pg:Bo) recovered bone weight. The bones of OVX mice showed lower BMD than that of Sham mice, and the Pg:Bo = 3:1 restored the decreased BMD. Single treatment with Pg or Bo did not alter OC formation; however, the Pg:Bo = 3:1 inhibited OC formation.”
According to the news editors, the research concluded: “In addition, Pg and Bo lowered the OVX-induced elevation in blood glucose level. Thus, we suggest that Pg in combination with proper materials, such as Bo, might be a potential candidate treatment with minimal side effects protect against postmenopausal osteoporosis.”
