Drug discovery is a complicated and expensive process that can take years for a drug to finally come to market. In this week's podcast we walk you through the process of drug discovery looking through the lens of cystic fibrosis. We explain the many steps including screens for different drug compounds, the different phases of testing and the vast regulations that drugs in the US are under to protect people! Finally, we link this back to COVID-19 and some of the drugs that are currently being tested to see if they help...
Drug discovery is a complicated and expensive process that can take years for a drug to finally come to market. In this week's podcast we walk you through the process of drug discovery looking through the lens of cystic fibrosis. We explain the many steps including screens for different drug compounds, the different phases of testing and the vast regulations that drugs in the US are under to protect people! Finally, we link this back to COVID-19 and some of the drugs that are currently being tested to see if they help treat COVID-19 symptoms.
// SOURCES:
Sources
Cystic Fibrosis: https://www.cff.org/a
Cystic Fibrosis: https://www.cff.org/Research/About-Our-Research/Research-Milestones/
Cystic Fibrosis: https://ghr.nlm.nih.gov/gene/CFTR#:~:text=Normal%20Function,%2C%20tears%2C%20and%20digestive%20enzymes.
Ivacaftor discovery: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770629/pdf/dddt-7-929.pdf
Original Ivacaftor screen: https://pubmed.ncbi.nlm.nih.gov/16443646/
Ivacaftor company: https://investors.vrtx.com/news-releases/news-release-details/fda-approves-kalydecotm-ivacaftor-first-medicine-treat
Ivacaftor clinical trials: https://www.clinicaltrialsarena.com/projects/ivacaftor-treatment-for-cystic-fibrosis/
Follow-up characterization: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773991/
Drug discovery process: https://www.ncbi.nlm.nih.gov/books/NBK22930/
Drug discovery process http://phrma-docs.phrma.org/sites/default/files/pdf/rd_brochure_022307.pdf
Drug discovery process: https://www.fda.gov/drugs/development-approval-process-drugs
Drug failure/approval: https://blogs.sciencemag.org/pipeline/archives/2019/05/09/the-latest-on-drug-failure-and-approval-rates
COVID-19 Treatments: https://www.covid19treatmentguidelines.nih.gov/antiviral-therapy/chloroquine-or-hydroxychloroquine/
COVID-19 Treatments: https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-issues-emergency-use-authorization-potential-covid-19-treatment
Right to Try: https://www.fda.gov/patients/learn-about-expanded-access-and-other-treatment-options/right-try
Hydroxychloroquine shortage: https://www.arthritis.org/drug-guide/medication-topics/plaquenil-shortage
Hydroxychloroquine shortage: https://www.lupus.org/news/fda-recognizes-hydroxychloroquine-and-chloroquine-shortages
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