Endocannabinoid System Explained: Why Cannabis Affects Everyone Differently

Why do two people take the same cannabis product and have completely different experiences? The answer may be hidden in your DNA.

In this episode, we explore how the endocannabinoid system works and why personalized medicine is becoming essential in modern healthcare. Len May shares his journey from early cannabis use for ADHD to building a platform that combines human genetics with plant science. The conversation dives into how cannabinoids like THC and CBD interact with the body, how genetic markers influence stress response and metabolism, and why dosage and composition matter more than strain names.

We also discuss the limitations of a one-size-fits-all approach in medicine and how emerging tools like pharmacogenomics and AI-driven platforms are helping practitioners create more individualized treatment plans. From inflammation and mood regulation to neuroplasticity and psychedelic therapies, this episode highlights the importance of understanding your unique biology before choosing any intervention.

If you are exploring cannabis, psychedelics, or regenerative therapies, this conversation offers a grounded, science-informed perspective on how personalization can improve both safety and outcomes.