In this episode, we set the stage by going through the intricate anatomy of the gut lining, providing a comprehensive understanding of its layers and cellular components. We, then, explore how six gut-supporting peptides and compounds offer promising therapeutic avenues. From larazotide acetate's tight-junction regulation to KPV's anti-inflammatory properties and BPC-157's reparative effects, we dive into the diverse mechanisms by which these peptides contribute to gut health.
Topics: 1. Anatomy of the Gut Lining
- Layers of Mucus
- Varying thickness in different parts of the intestine
- Composition: water, mucins, glycoproteins
- Intestinal Epithelium
- Tight junctions
- Renewal every 3 to 5 days
- Villi and Crypts
- Increase in surface area
- Stem cells in crypts for cellular renewal
- Microvilli
- Amplification of absorptive surface area
2. Lamina Propria
- Contains blood vessels and lymphatic vessels
- Rich in immune cells:
- Lymphocytes (T cells, B cells)
- Macrophages
- Dendritic cells
- Mast cells
- Eosinophils
3. Types of Epithelial Cells
- Enterocytes
- Goblet cells
- Paneth cells
- M cells
- Enteroendocrine cells
- Stem cells
4. Tight Junctions
- Composition: claudins, occludin, junctional adhesion molecules
- Interaction with cytoskeleton (ZO proteins)
- Dynamic regulation
- Role in permeability
5. Disruption of Tight Junctions
- Zonulin release
- Mechanism of increased permeability
6. Gut-Supporting Peptides and Compounds
- Larazotide acetate (AT-1001)
- Tight-junction regulator (think "leaky gut")
- Zonulin receptor antagonist
- KPV
- Sequence of amino acids from alpha-MSH
- Anti-inflammatory
- BPC-157 (Body Protection Compound)
- Derived from human gastric juice
- Protective and reparative effects
7. Additional Gut-Supporting Peptides
- Suprefort Pancreas peptides
- Svetinorm Liver peptides
- Stamakort Stomach peptides
Thanks for tuning in!
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