The CRISPR Conundrum: Sickle Cell, and Health Equity

Welcome to the Black Doctors Podcast with Dr. Steven Bradley, discussing the groundbreaking yet morally challenging first FDA-approved CRISPR therapy for sickle cell disease.

Takeaways:

1. The CRISPR therapy manipulates a patient's blood forming stem cells to increase fetal hemoglobin, significantly reducing pain crises and organ damage associated with sickle cell disease. However, the therapy costs around $2 million, plus additional hospitalization and treatment expenses.

2. Access to this potentially transformative therapy raises ethical issues, including high costs, logistical complexities, and the fact that sickle cell disease disproportionately affects Black Americans. Many patients may not be able to navigate the path to treatment due to geographic and economic disparities.

3. Proposed solutions include outcome-based payment models, specialized treatment centers with supporting infrastructure, and the need for transparent, inclusive processes to ensure equitable access. Pricing models must reflect the societal investment in public and charitable funding.

Conclusion:

Turning this scientific breakthrough into a social one requires moral and financial innovation. Affordable and accessible CRISPR therapy for sickle cell disease is not just beneficial—it’s an ethical necessity.

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In-house music and audio production, so any ideas for improvements or suggestions for future guests are welcome. Visit www.StevenBradleyMD.com to learn more about our host. He is available for consultations or speaking engagements regarding health equity and medical ethics.

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