Roland Pankewich on Mitochondria and the Gut Health Connection

A mind-blowing conversation with mitochondrial health expert Roland Pankewich on the science of mitochondria, the connection between mitochondrial and gut health, how mitochondria communicate with gut microbiota, strategies to improve both gut and mitochondrial function and much more...

 

 

Bio: 

 

Roland Pankewich is the CEO of Health Optimization Practice Canada and the owner/operator of the country’s first Health Optimization Clinic. His focus within his clinical practice is to work with high performing individuals, including business owners and professional athletes to help them find optimal health and performance in their lives. His specialty is in the deep understanding of the gut-immune system and how to optimize its structure and function. This allows him to share his insights and research with clients and other professionals in order to help them better understand their own health.

 

Topics discussed:

How Roland met Mitochondrial health expert and mentor Ted Achacoso

What are mitochondria?

"Powerhouse of the cell definition" from 1957

Cellular currency - ATP

The importance of cellular energy

Mitochondrial sensing- “The cell danger response"

Cell lifespan

Calcium metabolism

Epigenetic control

Deuterium depleted matrix water

Uncoupling of mitochondrial proteins (UCPs) and thermal heat 

The Fourth Phase of water- Gerald Pollack

https://www.amazon.com.au/Fourth-Phase-Water-Beyond-Liquid-ebook/dp/B00N2ASKF2

Exclusion Zone (EZ) water- battery

Mitochondrial dysfunction and disease

Mitochondria and cell nucleus communication

Oxidation and Reduction agents (REDOX)

Pattern recognition receptors (PRR)

Damage associated molecular patterns (DAMPS)

Pattern associated molecular patterns (PAMPS)

Bacterial antigen binding to mitochondrial receptors

Cross mitochondria communication

Mitochondria - ancient archaea

Mitochondria - immune system alert and activation

What are reactive oxygen species (ROS) free radicals?

What is REDOX?

ROS signalling molecules

What is apoptosis?

What is necrosis?

The mitochondrial engines ATP synthase

Protein gradient and spin to produce ATP

Aerobic respiration vs fatty acids

Electron chain transport

Electron leakage and free radical production

Where is the highest concentration of mitochondria in the body?

The gut mitochondria connection

The Gut- last line of defence in the body

Mitochondria and gut microbiome interaction

PGC1 alpha, AMPK, SIRTUINS

What happens locally impacts the body systemically 

Why do we see disease manifested in the gut first?

Microbiome imbalance and inflammatory cascade

Gut- absorption system first and barrier second

Leaky gut, the tipping point

Immune system- Hurt or Heal

Tight junction proteins

Microbiota development for optimal host symbiosis 

Creating a harmonious environment for your microbiota and mitochondria

Gut Unicorns

How do mitochondria and microbiota communicate bidirectionally 

Microbiota metabolites for mitochondrial fuel

Short-chain fatty acids

Urolithins- Mitochondrial biogenesis 

Up-regulation of transcription factors PGC1 alpha, AMPK, SIRTUINS and fat metabolism

Mitochondria and gut barrier function

Redox status of the cell, gut barrier, microbiota and mitochondrial function

Metabolites Hydrogen sulphide, nitric oxide and mitochondrial energy production

Butyrate production - fuel for enterocytes

A new gut lining every 3 to 5 days

Drug targeting and microbiota

Molecular mimicry and autoimmune disease

How do we improve mitochondrial function?

Metabolic flexibility

Time-Restricted Eating

Cofactor for Mitochondrial Health

Micronutrient Dense Diet

Walking, High Intensity and Resistance Training

Optimising your Digestive System

Food Choices for optimal gut health

Variety of Plant foods for Microbiota diversity

What is Hormesis?

Intermittent Fasting

Cold Exposure and Sauna

Antioxidants, polyphenols and microbiota diversity 

Autophagy vs Mitophagy vs Mitochondrial biogenesis

Clinical examples- Weight loss

Clinical examples- Gut health

Evolutionary Biology

Roland’s top tip for Gut Health

 

Brought to you by:

 

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Connect with Roland Pankewich

 

Website- https://www.rttrcorp.com/

 

 

Connect with Kriben Govender: 

 

Facebook- https://www.facebook.com/kribengee/

Instagram- https://www.instagram.com/kribengovender/

Youtube- https://www.youtube.com/c/Nourishmeorganics?sub_confirmation=1

Gut Health Gurus Facebook Group: https://www.facebook.com/groups/nourishmeorganics/

Deuterium Depletion Support Facebook Group: https://www.facebook.com/groups/347845406055631/

 

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