730 Patients were randomized to receive daily oral aprocitentan or placebo, plus a fixed-dose combination of amlodipine, valsartan, and hydrochlorothiazide.
After 4 weeks, mean change in office systolic BP was 15 mm Hg with aprocitentan and 11 mm Hg with placebo; this 4 mm difference was statistically significant.
What is the cost? What is the long term effects? Why didn't they compare this to the standard of care spironolactone?
https://www.hcplive.com/view/fda-approves-aprocitentan-tryvio-for-treatment-resistant-hypertension
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(22)02034-7/abstract
Episode 283: 282. New Guidelines For Management of Acute Pancreatitis
Episode 282: 281. What Do You Do With Elevated Childhood Cholesterol?
Episode 281: 280. How Much Weight Does an Obese Mother Need to Gain?
Episode 280: 279. Does Sitting In a Chair Improve Patient Stay in the Hospital?
Episode 279: 278. Does a Swiss Ball Help During Labor and Delivery?
Episode 278: 277. What Do You Do With Subclinical Hypothyroidism?
Episode 277: 276. REDUCE-MI Trial- Should we still Give BBlockers Post-MI?
Episode 276: 275. Do SSRI Increase The Rate Of Bleeding With Anticoagulants?
Episode 275: 274. Do Your Genes ACTUALLY Make You Obese?
Episode 274: 273. Does Telerehabilitation Work For Chronic Knee Pain?
Episode 273: 272. Does Bariatric Surgery Work in Diabetics For Cardiovascular Events
Episode 272: 271. Cologaurd Has a New Test? How Good is it?
Episode 270: 269. What is the Harm in Aspirin?
Episode 268: 268. New Guidelines For Total Hip and Knee Joint Replacement
Episode 269: 267. Beta Blockers DON'T Help Post-MI
Episode 267: 266. How Many Years Of Smoking Cessation Do You Need?
Episode 266: 265. Semaglutide and Cardiovascular Events in Non-Diabetics (secondary prevention) SELECT TRIAL
Episode 265: 264. Does a Lidocaine Patch Work for Neck Pain?
Episode 264: 263. Rates of Atrial Fibrillation 12 months After Onset of Hospitalized Transient AF
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