A study that was done before the widespread use of troponin only measurements for ACS (and certainly before high sensitively trop EVER EXISTED), a trial that took place before the first statin was even FDA approved, a trial that had no idea what DAPT was and took place PRIOR to the publication of the trial that would ultimately make aspirin post MI a standard of care, a trial that existed before a standard 90 minute door to balloon time.
As a reminder this trial (ISIS) didn’t demonstrate a huge mortality benefit despite all of the things that were missing from it that are now considered standard of care. The mortality number needed to treat was 143 (13.3% vs 14.0%)
https://www.nejm.org/doi/abs/10.1056/NEJMoa2401479
Episode 283: 282. New Guidelines For Management of Acute Pancreatitis
Episode 282: 281. What Do You Do With Elevated Childhood Cholesterol?
Episode 281: 280. How Much Weight Does an Obese Mother Need to Gain?
Episode 280: 279. Does Sitting In a Chair Improve Patient Stay in the Hospital?
Episode 279: 278. Does a Swiss Ball Help During Labor and Delivery?
Episode 278: 277. What Do You Do With Subclinical Hypothyroidism?
Episode 276: 275. Do SSRI Increase The Rate Of Bleeding With Anticoagulants?
Episode 275: 274. Do Your Genes ACTUALLY Make You Obese?
Episode 274: 273. Does Telerehabilitation Work For Chronic Knee Pain?
Episode 273: 272. Does Bariatric Surgery Work in Diabetics For Cardiovascular Events
Episode 272: 271. Cologaurd Has a New Test? How Good is it?
Episode 271: 270. Aprocitentan, How Well Does it Work for Resistant Hypertension?
Episode 270: 269. What is the Harm in Aspirin?
Episode 268: 268. New Guidelines For Total Hip and Knee Joint Replacement
Episode 269: 267. Beta Blockers DON'T Help Post-MI
Episode 267: 266. How Many Years Of Smoking Cessation Do You Need?
Episode 266: 265. Semaglutide and Cardiovascular Events in Non-Diabetics (secondary prevention) SELECT TRIAL
Episode 265: 264. Does a Lidocaine Patch Work for Neck Pain?
Episode 264: 263. Rates of Atrial Fibrillation 12 months After Onset of Hospitalized Transient AF
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