Fifty episodes. That’s fifty (sometimes) deadly viruses, bacteria, protozoa, parasites, and poisons. And don’t forget the fifty quarantinis to accompany each! What better way to celebrate this momentous occasion than talking about something that may actually save you: antibiotics. In this, our golden anniversary episode, our ambition tempts us to tackle the massive world of these bacteria-fighting drugs. We explore the various ways that antibiotics duel with their bacterial enemies to deliver us from infection, and we trace their history, from the early years of Fleming and Florey to the drama-laden labs of some soil microbiologists. Finally, we end, as we always do, with discussing where we stand with antibiotics today. Dr. Jonathan Stokes (@ItsJonStokes), postdoctoral fellow in Dr. Jim Collins’ lab at MIT, joins us to talk about some of his lab’s amazing research on using machine learning to discover new antibiotics, which prompts us to repeat “that is SO COOL” and “we are truly living in the future.” We think you’ll agree.
To read more about using machine learning to uncover antibiotic compounds, head to the Collins’ lab website, the Audacious Project site, or check out Dr. Stokes’ paper:
Stokes, Jonathan M., et al. "A deep learning approach to antibiotic discovery." Cell 180.4 (2020): 688-702.
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Ep 139 Supplements: “This statement has not been evaluated by the FDA”
Ep 138 Fever: Take it to the limit
Special Episode: Dr. Deirdre Cooper Owens & Medical Bondage
Ep 137 ME/CFS: What’s in a name? (A lot, actually)
Ep 136 Long Covid: A long time coming
Ep 135 Menopause is whatever you want it to be
Ep 134 Tonsils: Underestimated and underappreciated
Ep 133 Parvoviruses: Who let the dogs (and their viruses) out?
Ep 132 Osteogenesis Imperfecta: All bones about it
Ep 131 Parkinson’s Disease: Dopamine & discoveries
Ep 130 Cocoliztli: We do love a salty dish
Ep 129 Lymphatic Filariasis: Hiding in plain sight
Ep 128 Skin Cancer: We love and fear the sun
Ep 127 Bhopal: The 1984 Union Carbide Disaster
Ep 126 Migraine: A Cacophony in Four Movements
Ep 125 Blastomycosis: How fungus became amongus
Ep 124 The full spectrum of color vision deficiency
Ep 123 Hand, Foot, and Mouth (and Butt?) Disease
Ep 122 Asthma: A phlegmy episode
Special Episode: Ed Yong & An Immense World
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