On AIRR - Immune receptors in the clinic
Science:Life Sciences
Dr. Corey Watson is an Associate Professor at the University of Louisville. His work focuses on characterising and cataloguing antibody genetic diversity in human and mouse to better understand disease susceptibility and clinical health outcomes. Dr. William Lees is a researcher at University of London. His work focuses on developing Adaptive Immune Receptor (AIR) reference sets for diverse species and the annotation of experimental sequence data.
In this episode we talk about the recent work by the Germline Database Working Group of the AIRR-Community. The accuracy of V and J gene segment assignment improves with the quality of the reference germline set. The accurate assignment is critical for characterization of somatic hypermutation. We discuss the challenges in creating a database to hold all relevant and potentially relevant germline information, especially in the light of increased discovery rate through technological advances and improved analysis pipelines. We also reflect on the complexity in handling personalised germline reference sets.
The episode is hosted by Dr. Ulrik Stervbo and Dr. Zhaoqing Ding.
Comments are welcome to the inbox of onairr@airr-community.org or on social media under the tag #onAIRR. Further information can be found here: https://www.antibodysociety.org/the-airr-community/airr-c-podcast.
Website of the AIRR-C Germline Database Working Group
Papers mentioned
Tools mentioned
On AIRR 14: Data protection and data sharing with Alexander Bernier
On AIRR 13: Disease diagnostics using machine learning with Maxim Zaslavsky and Dr. Scott D. Boyd
On AIRR 12: T-cell receptor-mimetic antibodies and immunoinformatics with Prof. Dr. Charlotte Deane
On AIRR 11: Software as a Medical Device (SaMD) with Dr. Xenophon Papademetris
On AIRR 10: Characterising B Cell Lymphomas or Profiting from a Focus on B Cells in Health and in Disease with Dr. Ralf Küppers
On AIRR 9: The ImmunoMind or wielding an AI for repertoire insights with Vadim Nazarov
On AIRR 8: Engineering B cells or Giving the immune System an Optimal Starting Point with Dr. Adi Barzel
On AIRR 7: Quality Controls in AIRR-Seq Assays or Handling the Catastrophe with Dr. Encarnita Mariotti-Ferrandiz
On AIRR 6: Data Sharing or Finding Glory, Fame and a Big Pile of Gold with Dr. Brian Corrie and Dr. Scott Christley
On AIRR 5: Machine learning and AIRR or Looking for the needle in a needle stack with Dr. Lindsay Cowell and Dr. Victor Greiff
On AIRR 4: Understanding and engineering immune repertoires with Dr. Jacob Glanville
On AIRR 3: Outlining chronic lymphocytic leukemia with Dr. Anton Langerak
On AIRR 2: Establishing an AIRR-Seq framework with Dr. Lindsay Cowell
On AIRR 1: MRD with Dr. Luning Prak
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