Modern Healthspan

Why Does Fasting Weaken Cancer But Save Healthy Cells? | Dr Valter Longo

Dr. Valter Longo explains how fasting-mimicking diets make cancer cells vulnerable to treatment while protecting healthy tissue, plus the clinical evidence, safety protocols, and why oncologists remain skeptical.Dr. Valter Longo, author of "Fasting Cancer," breaks down decades of research on using fasting-mimicking diets (FMD) alongside conventional cancer therapies. Cancer cannot be starved but it can be metabolically weakened by limiting resources which a the same time protects healthy cells. A process known as differential stress resistance. We cover: the mechanism behind why this works, clinical trial results in triple-negative breast cancer and other aggressive cancers, the surprising data on weight loss and cachexia, BMI cutoffs and safety protocols, how to approach your oncologist, prevention versus treatment applications, and the cutting-edge "escape pathway" research that could transform personalized cancer treatment. Dr Longo addresses the elephant in the room: why, despite promising results in both mouse models and human trials, this approach faces massive institutional and regulatory barriers to becoming standard of care. Practical, evidence-based information for patients, caregivers, and anyone interested in the intersection of nutrition and cancer biology.🌐Links in this video Create Cures Foundation https://createcures.org/ - Dr Longo organization in the US The Valter Longo Foundation https://www.fondazionevalterlongo.org/en/ - Dr Longo's organization in Italy and rest of the world Dr Longo's website https://valterlongo.com/ Facebook https://www.facebook.com/profvalterlongo/ Instagram https://www.instagram.com/prof_valterlongo/ Fasting Mimicking Diet company Prolon https://prolonlife.com/*Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters PowderSeeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Are Mitochondria the Real Driver of Aging? | Dr Luigi Ferrucci

Dr. Luigi Ferrucci reveals what 60 years of Baltimore Longitudinal Study data shows about aging, inflammation, mitochondria, and the biomarkers that predict your health trajectory.In this conversation, Dr. Luigi Ferrucci, Scientific Director of the National Institute on Aging and director of the Baltimore Longitudinal Study of Aging, shares insights from the longest-running scientific study of human aging.We discuss why measuring the pace of aging matters more than a single snapshot, how mitochondrial function drives the entire aging process, and why chronic inflammation may be a secondary response rather than a primary cause of aging. Dr. Ferrucci reveals which biomarkers should be in clinical use right now (including GDF-15), what the BLSA data shows about people who age successfully, and the specific lifestyle factors that add nine years of healthy life expectancy.This is essential viewing for anyone interested in longevity science, biological age testing, and evidence-based interventions to slow aging. Dr. Ferrucci brings decades of rigorous research to questions about what actually works and what we're still learning.🌐Links in this video Dr Ferrucci's page at the NIA https://irp.nih.gov/pi/luigi-ferrucciBaltimore Longitudinal Study of Aging main site https://www.nia.nih.gov/research/labs/blsaThe Baltimore Longitudinal Study of Aging (BLSA): A 50-Year-Long Journey and Plans for the Futurehttps://pmc.ncbi.nlm.nih.gov/articles/PMC5004590/#longevity #healthspan #aging*Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters PowderSeeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Creatine for Your Brain: The Dosing Most People Get Wrong | Dr Dan Pardi

Dr. DanPardi explains why creatine supplementation may help preserve cognitivefunction during sleep deprivation, aging, and high mental demand, plus thespecific dosing strategies most people miss. In thisconversation, Dr. Dan Pardi breaks down the emerging science of creatine forbrain health. While creatine is famous for athletic performance, new researchshows it may help maintain cognitive function under stress, particularly duringsleep deprivation, travel, and aging. Dr. Pardi explains the mechanisms: howcreatine acts as an energy buffer in the brain, why it works best under fatigueor high demand, and which cognitive functions respond most consistently(working memory, processing speed, sustained attention). We cover practicaldosing strategies, including why 5 grams daily may not be enough for brainbenefits, the role of loading phases, and the specific high-dose protocolstudied for sleep deprivation. This isn't about cognitive enhancement; it'sabout preservation. If you're interested in maintaining brain performance asyou age, dealing with poor sleep, or supporting cognitive resilience, thisconversation offers actionable strategies backed by research. 🌐Linksin this video Qualia LifeSciences web page https://www.qualialife.com/Human OSwebsite https://humanos.me *Qitone*(10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters PowderSeekingHealth supplements: 10% discount code Richard10https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrientshttps://crrnt.app/SEEK/EpM7paAOAX3 LifeAstaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15%discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Scienceall 10% discount with code MHS https://renuebyscience.com/  Nuchido Time+ 20% discount offirst purchase with code MODERN20 https://nuchido.com/MODERNIf you would like tosupport our channel please consider signing up on patreonhttps://patreon.com/ModernHealthspanYou can also find us onYouTube at https://www.youtube.com/c/modernhealthspan

This Dietary Change Could Save Your Vision | Dr Allen Taylor

Dr. Allen Taylor spent 40 years at Tufts discovering how diet affects vision. Learn why high glycemic foods accelerate macular degeneration and cataracts—and what you can do to protect your eyes.Dr. Allen Taylor directed the Laboratory for Nutrition and Vision Research at Tufts University for four decades, pioneering groundbreaking discoveries about how nutrition impacts age-related eye diseases. In this comprehensive interview, he reveals how high glycemic diets create a "double jeopardy" in your eyes—damaging proteins while simultaneously destroying your cellular cleanup systems.Dr. Taylor explains the cellular mechanisms behind age-related macular degeneration (AMD) and cataracts, breaking down complex biochemistry into actionable insights. You'll learn about the epidemiological evidence linking Western diets to AMD risk, why blood sugar spikes matter even for non-diabetics, and how advanced glycation end products (AGEs) accumulate in retinal tissue.The conversation covers practical strategies including which antioxidants matter most (vitamin C, vitamin E, lutein), why omega-3 fatty acids support retinal health, and how switching from high to low glycemic foods could prevent 100,000 cases of blinding AMD annually. Dr. Taylor also discusses his current intervention trial testing whether people with early AMD can preserve vision through dietary changes.Key topics: macular degeneration, cataracts, glycemic index, nutrition and vision, eye health, aging, preventive medicine, antioxidants, drusen, photoreceptor health, retinal pigment epithelium, and practical dietary interventions for longevity🌐Links in this video Dr Taylor's page at Tufts https://facultyprofiles.tufts.edu/allen-taylor The review mentioned by Dr Taylor: Glycative stress as a cause of macular degeneration Full Version: https://tinyurl.com/bdp3u93f Summary Version: https://tinyurl.com/yj2zmx5n*Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters PowderSeeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan

Is This The Cause of All Chronic Diseases | Dr Douglas Kell

Your ferritin test doesn't measure what you think. Dr. Douglas Kell explains iron dysregulation, dormant microbes, and his controversial theory about chronic diseaseDr. Douglas Kell, systems biologist at the University of Liverpool, presents his research on iron dysregulation and its potential role in chronic inflammatory diseases. In this conversation, he explains why ferritin in blood is actually a marker of cell death rather than iron storage, how free iron can trigger oxidative stress through the Fenton reaction, and his hypothesis about dormant bacteria and amyloidogenic microclots. We discuss practical interventions including what iron tests actually matter (transferrin saturation over ferritin), natural compounds like ergothioneine from mushrooms that showed dramatic protective effects in studies, and enzymes like nattokinase that may help address abnormal clotting. Dr. Kell also covers his work on pre-eclampsia, the connection between iron and neurodegenerative diseases, and why he views most chronic inflammatory diseases through a systems biology lens. While his full IDDM (Iron Dysregulation and Dormant Microbes) hypothesis remains contested, the practical information on iron management and oxidative stress provides actionable insights for healthy aging.🌐Links in this video Dr Kell's page at University of Liverpool https://www.liverpool.ac.uk/people/douglas-kell DBK Group's web page with all Dr Kell's publications https://dbkgroup.org/*Qitone* (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters PowderSeeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAOAX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nwhttps://www.choosemuse.comStemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)Renue by Science all 10% discount with code MHS https://renuebyscience.com/ Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERNIf you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspanYou can also find us on YouTube at https://www.youtube.com/c/modernhealthspan