The Human Upgrade: Biohacking for Longevity & Performance

It's Weird, But It Turns On Your Body's Anti-Aging Switch Fast : 1487

Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/Try Suppgrade Labs: https://shopsuppgradelabs.com/If you're eating clean, taking the right supplements, and still feel exhausted and mentally foggy - the problem isn't your protocol. Your body has a built-in cellular cleanup system that determines whether any of those inputs actually work, and right now it's almost certainly switched off. In this video, I break down what that system is, how chronic stress and all-day eating suppress it without you ever feeling it, and the specific compounds that flip the longevity switch back on through independent biological pathways that nothing else touches.Thank you to our sponsors!ECHO Water | Go to http://echowater.com/daveand use code DAVE10 for 10% off your ECHO Flask.EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:0:00 – The Longevity Switch0:47 – Why Mitochondria Matter2:28 – What Mitophagy Is2:46 – How Mitophagy Works4:18 – What Shuts It Off8:54 – The Damage Compounds9:22 – How to Turn It Back On10:31 – Signal 1: Fasting11:48 – Signal 2: Exercise (REHIT)12:30 – Signal 3: Cold Exposure13:22 – Signal 4: NAD+14:29 – Signal 5: Urolithin A and SpermidineConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Sugar-Free Backlash, Taurine Fail, Copper Brain Therapy, Childhood Biohacking, Strength Training : 1488

Sugar-Free Diets Disrupted Gut Microbiome and Metabolism A 16-week sucrose-free, low-fat diet study presented at ENDO 2026 found mice developed insulin resistance, impaired glucose tolerance, gut microbiome imbalance, intestinal inflammation, and fatty liver disease signs despite no weight gain or calorie difference. Host Dave Asprey breaks down why eliminating sugar entirely may be more detrimental than previously thought, the gut-bacteria-to-metabolism cascade that explains the metabolic damage, and why balanced nutrition matters more than simply removing sugar from your stack. Sources: https://www.sciencedaily.com/releases/2026/06/260614011843.htm https://www.medicalnewstoday.com/articles/how-eliminating-sugar-may-alter-the-gut-microbiome-mouse-study https://nypost.com/2026/06/13/health/going-sugar-free-can-mess-with-your-gut-and-metabolism/ ~~ Taurine Did Not Boost Acute Aerobic Performance A randomized, triple-blind, cross-over study of 16 physically active young adults found acute 1-gram taurine ingestion one hour before exercise produced no significant improvements in peak oxygen consumption, time to exhaustion, respiratory compensation point, or lipid/glycolytic metabolism variables. Host Dave Asprey explains why taurine remains popular in energy drinks and pre-workouts despite limited scientific evidence, what dosages and activity types future research should test, and why a reality check on a billion-dollar supplement category is exactly the kind of truth biohackers need. Sources: https://pubmed.ncbi.nlm.nih.gov/42268287/ https://www.sciencedaily.com/releases/2026/06/260611024609.htm ~~ Copper Therapy Improved Memory and Reduced Alzheimer’s Proteins in Mice Lab trials from Monash University published in ACS Chemical Neuroscience found Cu(ATSM), a copper-delivery compound, increased P-glycoprotein abundance by 24.1 percent at the blood-brain barrier, reduced toxic amyloid-beta by 42 percent over 56 days, and improved spatial learning by nearly 44 percent in an Alzheimer’s mouse model. Host Dave Asprey breaks down why repairing the brain’s waste-clearing pump is a potential new therapeutic avenue for neurovascular dysfunction, why Cu(ATSM) has strong potential to fast-track into human clinics since it’s already tested for Parkinson’s and ALS, and why biometal therapies like this could be the next frontier in Alzheimer’s treatment. Sources: https://www.news-medical.net/news/20260615/Lab-trials-prove-copper-therapy-enhances-cognitive-function-and-spatial-learning.aspx https://www.monash.edu/news/articles/copper-drug-restores-memory-and-clears-toxic-alzheimers-proteins https://pubs.acs.org/doi/10.1021/acschemneuro.6c00252 ~~ Socioeconomic Factors Biologically Embedded in Children’s Brains A study of 2,300+ 9- and 10-year-olds published in Science found socioeconomic factors—household income, education, neighborhood quality—were the dominant variable affecting brain development, with MRI-visible differences in sensory processing and motor control regions linked to less sleep, more stress, and higher social media use in lower-income neighborhoods. Host Dave Asprey explains why socioeconomics became “biologically embedded” in preteen brains, how sleep-stress-screen circuits alter wakefulness and alertness, and why earlier studies focusing on IQ or mental health without accounting for environment may require reevaluation. Sources: https://www.npr.org/2026/06/11/nx-s1-5849937/child-brain-development-stress-sleep-neighborhood-economics https://abcdstudy.org/ ~~ Strength Training Sweet Spot for Longevity Is 90–120 Minutes Per Week A 30-year observational study of 147,374 participants published in the British Journal of Sports Medicine found 90–119 minutes per week of strength training delivered 13 percent lower all-cause mortality, 19 percent lower cardiovascular mortality, and 27 percent lower neurological mortality, with no additional benefit above 120 minutes. Host Dave Asprey breaks down why more isn’t always better when it comes to resistance training, why combining strength with aerobic exercise dropped mortality risk by 45–58 percent at highest levels, and why 15–20 minutes a day or 30–40 minutes three times weekly is the minimum effective dose for longevity. Sources: https://www.sciencedaily.com/releases/2026/06/260611024609.htm https://academic.oup.com/sleep/article/48/8/zsaf127/8129074 https://www.bmj.com/content/bsjspor/early/2025/06/11/bjsports-2025-110503 ~~ This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on sugar-free diet metabolic risks, taurine supplement efficacy, copper-based Alzheimer’s therapeutics, childhood environmental brain development, and strength training longevity dosing. Host Dave Asprey connects preclinical animal data, randomized human trials, observational cohort research, and population neuroscience into actionable frameworks for extending healthspan, optimizing metabolism, and staying ahead of the science. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: sugar-free diet gut microbiome, insulin resistance sugar elimination, taurine aerobic performance, taurine supplement myths, Cu(ATSM) copper Alzheimer’s therapy, blood-brain barrier P-glycoprotein, amyloid-beta reduction copper drug, spatial learning Alzheimer’s mouse, socioeconomic brain development children, ABCD Study brain MRI, childhood biohacking environment, strength training longevity 90-120 minutes, British Journal Sports Medicine strength, weekly strength training dose, all-cause mortality resistance training, biohacking news 2026, longevity researchThank you to our sponsors! - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body. - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Intro 0:20 – Story 1: Copper & Alzheimer's 2:42 – Story 2: Sugar-Free Diet 4:05 – Story 3: Strength Training Minimum Dose 5:48 – Story 4: Childhood Environment & Brain Development 7:42 – Story 5: Taurine 9:49 - Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

BDNF Superpowers Through MDMA and Ketamine | Dr. Dave Rabin : 1486

Ketamine Therapy, MDMA, Psilocybin, and the Science of Psychedelic Assisted Healing Most people struggling with depression, anxiety, and trauma have never felt safe in their nervous system, and the treatments they have been prescribed are making that worse. This episode breaks down the neuroscience of psychedelic therapy, why ketamine is the safest and most accessible starting point, how MDMA triggers a BDNF dependent pathway that repairs trauma all the way down to the epigenetic code, and why your antidepressant may be blocking the very brain states required for real healing. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Order Dr. Rabin’s Book ‘A Simple Guide to Being Alive’: https://apolloneuro.com/pages/a-simple-guide-to-being-alive Host Dave Asprey sits down with Dr. Dave Rabin, MD, PhD, a senior research scientist at the Florida Institute for Human and Machine Cognition, Executive Director of The Board of Medicine, and co-founder and Chief Medical Officer of Apollo Neuroscience. Dr. Rabin received his MD and PhD in neuroscience from Albany Medical College and specialized in psychiatry at the University of Pittsburgh Medical Center. He has spent 20 years studying chronic stress and non-invasive therapies for treatment-resistant illness, and his primary research on MDMA assisted therapy for severe PTSD has demonstrated that trauma can be reversed at the epigenetic level, offering a genuine path to a cure. His upcoming book A Simple Guide to Being Alive publishes June 1, 2026 and is a science-backed manual for anyone who has ever felt overwhelmed by the modern world. Dave and Dr. Rabin break down why nearly 50% of people prescribed psychiatric medication never achieve remission, why SSRIs and SNRIs physically block the brain states required for emotional healing, and why the FDA rejected MDMA therapy after three trials showed an 88% response rate. They dig into the exact BDNF pathway that makes MDMA and ketamine so transformative, how psychedelics amplify safety learning in the amygdala at the molecular level, and why trauma passes down up to 14 generations through epigenetic code that can now be measured and repaired. They also cover why your breathing rate at the doctor's office is already a stress signal nobody is reading, how your smartphone puts your nervous system into a chronic fear state before you even get out of bed, and why ketamine is the right starting point for anyone curious about psychedelic therapy right now. You'll Learn: Why nearly 50% of psychiatric patients never get better and what treatment-resistant actually means How ketamine therapy works, why it is legal in every state, and why it is the safest place to start The exact BDNF pathway through which MDMA repairs fear extinction in the amygdala How MDMA assisted therapy produces measurable epigenetic repair of the cortisol receptor gene damaged by trauma Why SSRIs and SNRIs block the insula mediated brain states required for real emotional healing Why combining serotonergic psychedelics with SSRIs puts you at risk of life-threatening serotonin syndrome Why trauma passes down up to 14 generations and what you can do to stop the cycle now Why smartphones put your nervous system into a toxic overstimulation state before the day even starts How the FDA rejected MDMA therapy after 88% of patients responded and who paid to make that happen Thank you to our sponsors! - Qualia | If you want to take the guesswork out of maintaining high NAD+ levels as you age, go to www.qualialife.com/daveNAD to get clinically proven Qualia NAD+ backed by a 100 day money back guarantee and code DAVENAD at checkout gets you an extra 15% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - OneSkin | For a limited time, try OneSkin with 15% off at oneskin.co/DAVE. - LMNT | Right now you can get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinkLMNT.com/dave Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dave Rabin, Dr. Dave Rabin, Apollo Neuroscience, A Simple Guide to Being Alive, ketamine therapy, MDMA assisted therapy, psilocybin therapy, psychedelic assisted therapy, treatment-resistant depression, treatment-resistant mental illness, BDNF pathway, fear extinction amygdala, vagus nerve activation, trauma epigenetics, cortisol receptor gene, epigenetic repair, serotonin syndrome, SSRI alternatives, MDMA BDNF, ketamine BDNF, nervous system safety, autonomic nervous system, parasympathetic nervous system, generational trauma, trauma self-trust, MAPS MDMA trial, FDA MDMA rejection, pharmaceutical interference MDMA, breathing rate stress, smartphone nervous system, Apollo Neuro wearable, Board of Medicine, theboardofmedicine.org, insula cortex, psychedelic safety protocol, ketamine legal therapy, MDMA 88 percent, bottom-up learning psychedelics, trauma fractured self-trust, 14 generations trauma, stress breathing range Resources: • Order Dr. Rabin’s Book ‘A Simple Guide to Being Alive’: https://apolloneuro.com/pages/a-simple-guide-to-being-alive • Purchase Dr. Fotuhi’s New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:34 – Dave Rabin Introduction 05:01 – Psychedelics and Psychiatry 08:35 – Psychedelic Safety and Dosing 14:53 – Serotonin Syndrome Warning 21:17 – Vagus Nerve and Safety 27:36 – Smartphones and Chronic Stress 34:18 – Defining Trauma 38:00 – Trauma and Epigenetics 40:23 – MDMA Cortisol Gene Repair 44:44 – Therapy vs. Medicine Alone 49:15 – FDA MDMA Rejection 55:35 – Ketamine Personal Experience 59:15 – Closing and Book Recommendation See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The Skin Mistakes That Age You Fast and Kill You Slow | Dr. Michael Christopher : 1485

Skin Cancer Prevention, Anti-Aging Biohacking, and the Melanoma Detection Gap Most dermatologists are missing melanoma, and a board-certified skin cancer specialist explains exactly why, and what to do about it. This episode covers the detection tool that finds 10 times more melanomas, the real truth about sunscreen chemicals, the biohacking peptide that can hide cancer on your skin, and the cheap anti-aging drug that most people have never tried. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Michael Christopher, a board-certified dermatologist and expert dermoscopist recognized for his work in early melanoma detection. Through consistent, evidence-based use of dermoscopy, he identifies between 150 and 215 melanomas annually, far exceeding national and state averages and exposing a critical gap in standard skin cancer screening. Dr. Christopher speaks regularly on prevention, early detection, and systemic failures in dermatology training across health, wellness, and longevity-focused media, and has made it his mission to change the standard of care before more people die from a cancer that is almost always curable when caught early. Dave and Dr. Christopher break down why a standard skin exam with no additional tools is essentially a guess, how dermoscopy changes everything, and why most dermatologists who claim to use it actually cannot interpret what they see. They get into the real risk factors for rising melanoma rates, what sunscreen labels are not telling you, and how melanotan and other biohacking peptides interact with your skin cancer risk in ways that matter. They also cover tretinoin as one of the most evidence-backed anti-aging and skin optimization tools available, how red lighttherapy supports mitochondria function and skin rejuvenation, and what parents should know about protecting their kids' skin for long-term longevity You'll Learn: Why most dermatologists miss melanoma and what the detection gap actually looks like What dermoscopy is, how it works, and why you should ask for it by name How melanoma survival drops from 99% at stage one to 73% at stage three What the Prop 65 cancer warning on most pharmacy sunscreens actually means Why visible light can darken your skin even when you wear sunscreen How melanotan activates melanocortin receptors and why that may affect melanoma risk What Retin-A does to collagen, the epidermis, and long-term skin aging How AI is entering dermoscopy and where it still falls short The right concentration of tretinoin to start with and how to get through the adjustment period What parents should do now to protect their kids from melanoma later Thank you to our sponsors! -Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.-Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.-Timeline | Go to timeline.com/dave and you’ll get an additional 20% off your first month-Redmond Real - Leaf Toothpaste | Go to https://redmond.com/asprey and use code ASPREY for 15% off your first order.Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Michael Christopher, Dr. Michael Christopher, melanoma detection, dermoscopy, dermatoscope, skin cancer screening, melanoma prevention, early melanoma detection, skin cancer biohacking, sunscreen toxins, Prop 65 sunscreen, mineral sunscreen, zinc oxide, titanium dioxide, melanotan, melanocortin, skin aging, anti-aging, tretinoin, Retin-A, retinol, skin rejuvenation, collagen, red light therapy, mitochondria, UV exposure, UVB light, skin cancer longevity, melanoma survival rate, squamous cell carcinoma, functional medicine, human performance, longevity, biohacking, supplements, skin optimization, dermoscopy AI, skin cancer AI, visible light tanning, omega-6 sunburn, astaxanthin, skin health, melanoma staging, skin exam, skin cancer prevention Resources: • Learn More About Dr. Christopher’s Work At: https://www.instagram.com/michael_christopher_md/ • Purchase Dr. Fotuhi’s New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Trailer 1:41 – Guest Introduction 3:59 – Dermatoscope Explained 12:27 – Melanoma Rising: Why 16:57 – Melanotan & Sun Risk 21:14 – Melanoma & Longevity 22:31 – Stage 1 vs Stage 3 26:05 – Retin-A Deep Dive 38:53 – Loose Skin Solutions 41:26 – Kids' Skin Health See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Just 1 Gram Activates Your Deep Focus Switch (Take THIS) : 1484

Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/Try Suppgrade Labs: https://shopsuppgradelabs.com/Over the last 15 years, I’ve built companies and spent millions testing what actually upgrades human performance, and I can tell you that mental fatigue has absolutely nothing to do with willpower. In this video, I break down the exact neurochemistry of deep focus. When your brain runs out of dopamine, norepinephrine, and acetylcholine, or gets bogged down by oxidative stress, your executive function collapses. The pharmaceutical industry wants you hooked on expensive stimulants that only treat the symptoms, but the real biological fix is a common antioxidant: Vitamin C.I explain how your brain hoards Vitamin C at levels 100 times higher than your blood, how to bypass the blood-brain barrier using SVCT2 transporters, and why eating sugar before you take it completely blocks its absorption. You'll also learn the exact biohacking stack—including NAC, CoQ10, PQQ, and L-theanine—you need to recycle this molecule, protect your mitochondria, and maintain effortless, razor-sharp focus all day long.Thank you to our sponsors!-KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off-Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – Trailer00:21 – Focus Is Biology01:53 – Brain Chemistry Explained05:33 – Vitamin C Revealed07:09 – How to Dose08:18 – Absorption Barriers09:31 – Optimize Uptake10:00 – Oxidative Stress Problem11:00 – Stack for Deeper FocusConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.