In this episode, Joan and Nir discuss their extensive research into rapamycin (including the category of analogs to rapamycin known as rapalogs) and metformin, respectively. Based on his work with metformin, Nir shares how he believes it could be a pro-longevity drug and the clinical trial he’s leading to test this belief. Joan discusses her work with rapalogs, their ability to suppress the immune system as well as provide immune-enhancement, and the clinical trials she has led that inform her insights. We also talk about the potential beneficial roles of both metformin and rapamycin in reducing mortality from COVID-19, reducing the risk of neurodegenerative diseases, and delaying aging as well as its related diseases.
We discuss:
Joan’s career, interest in aging, and work with rapamycin analogs [3:45]; When Nir became convinced metformin could be a pro-longevity agent [15:00]; How metformin and rapamycin impact the hallmarks of aging and extend lifespan [24:15]; Enhancing the immune system with rapalogs and metformin [34:15]; Potential of metformin and rapamycin in reducing mortality from COVID-19 [41:30]; Insights from Joan’s studies investigating the immune-enhancing effects of rapalogs [59:30]; Vaccines and treatments strategies for COVID-19, and the likelihood of long-term immunity [1:08:15]; The potential role of rapalogs and metformin in neurodegenerative disease [1:14:30]; Nir’s TAME trial—primary objectives and latest updates [1:18:00]; Potential synergistic effect when combining metformin with rapamycin [1:25:45]; Why Peter stopped taking metformin and started taking rapamycin [1:27:30]; Story from Nir’s book that demonstrates the challenge of doing good scientific studies [1:37:30]; The biology of aging—epigenetic clocks, proteomics, and Nir’s centenarian data [1:42:00]; Joan’s dream experiment to test immune-enhancing effect of RTB101 [1:57:15]; Concluding thoughts on COVID-19 [1:59:45]; and More.Learn more: https://peterattiamd.com/
Show notes page for this episode: http://peterattiamd.com/joanmannick-nirbarzilai/
Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/
Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/
Connect with Peter on Facebook | Twitter | Instagram.
#267 ‒ The latest in cancer therapeutics, diagnostics, and early detection | Keith Flaherty, M.D.
#266 - AMA #50: Genetics: how they impact disease risk, what you can do about it, testing, and more
#265 - Time, productivity, and purpose: insights from Four Thousand Weeks | Oliver Burkeman
#264 ‒ Hip, knee, ankle, and foot: common injuries, prevention, and treatment options
#263 ‒ Concussions and head trauma: symptoms, treatment, and recovery | Micky Collins, Ph.D.
#262 - AMA #49: Heart rate recovery, strength training, rucking, kidney function, and brain health
#261 ‒ Training for The Centenarian Decathlon: zone 2, VO2 max, stability, and strength | Peter Attia, M.D.
Cancer screening with full-body MRI scans and a seminar on the field of radiology | Rajpaul Attariwala, M.D., Ph.D. (#61 rebroadcast)
#260 ‒ Men’s Sexual Health: why it matters, what can go wrong, and how to fix it | Mohit Khera, M.D., M.B.A., M.P.H.
#259 - Women's sexual health: Why it matters, what can go wrong, and how to fix it | Sharon Parish, M.D.
#258 - AMA #48: Blood pressure—how to measure, manage, and treat high blood pressure
#257 ‒ Cognitive decline, neurodegeneration, and head injuries: mitigation and prevention strategies, supplements, and more | Tommy Wood, M.D., Ph.D.
#256 ‒ The endocrine system: exploring thyroid, adrenal, and sex hormones | Peter Attia, M.D.
#255 ‒ Latest therapeutics in CVD, APOE’s role in Alzheimer’s disease and CVD, familial hypercholesterolemia, and more | John Kastelein, M.D., Ph.D.
#254 - AMA #47: Cold therapy: pros, cons, and its impact on longevity
#253 ‒ Hormone replacement therapy and the Women’s Health Initiative: re-examining the results, the link to breast cancer, and weighing the risk vs reward of HRT | JoAnn Manson, M.D.
#252 ‒ Latest insights on Alzheimer’s disease, cancer, exercise, nutrition, and fasting | Rhonda Patrick, Ph.D.
The impact of stress on our physical and emotional health | Robert Sapolsky, Ph.D. (#51 rebroadcast)
#251 - AMA #46: Optimizing brain health: Alzheimer's disease risk factors, APOE, prevention strategies, and more
#250 ‒ Training principles for longevity | Andy Galpin, Ph.D. (PART II)
Create your
podcast in
minutes
It is Free
Good Mood Revolution
Huberman Lab
Good Nurse Bad Nurse
The Relaxback UK Show
On Call With Dr. Anselm Anyoha
The Doctor’s Farmacy with Mark Hyman, M.D.