A new generation of B-lactamase inhibitors is likely to reach the market in the upcoming year. These broad-spectrum inhibitors exhibit activity against the most feared class B metallo-B-lactamases maintaining the inhibition of other enzymes. Recently AAC has published three papers that describe the mechanistic bases of taniborbactam resistance among metallo-enzymes. This knowledge is crucial to understand the limitation of these compounds in clinical practice. Today, we will discuss this topic with some of the authors of the mentioned papers. Welcome to the editors in conversation.
Topics discussed:This episode of Editors in Conversation is brought to you by the Antimicrobial Agents and Chemotherapy Journal and hosted by AAC Editor in Chief, Cesar Arias.
AAC is available at https://asm.org/aac.
Follow Cesar on twitter at https://twitter.com/SuperBugDoc for AAC updates.
Subscribe to the podcast at https://asm.org/eic
Phages as Therapeutic Tools Against Multidrug Resistant Bacteria (AAC ed.)
COVID-19 Associated Pulmonary Aspergillosis - The Other CAPA (JCM ed.)
WHO Critical Review of the Antibacterial Pipeline (AAC ed.)
Testing for COVID-19 During the Age of Omicron (JCM ed.)
Best Clinical Microbiology Papers of 2021 (JCM ed.)
Treatment of Acinetobacter spp. Infections (AAC ed.)
SARS-CoV-2 Sequencing for Clinical Care and Infection Control (JCM ed.)
Candida auris at the Intersection of the COVID-19 Pandemic (AAC ed.)
COVID-19 Testing - Schools, False Positives, and In-Person Meetings (JCM ed.)
Testing for COVID-19 Infectivity (JCM ed.)
Treatment of VRE Infections (AAC ed.)
Advances in Serologic Testing for COVID-19 (JCM ed.)
Innovative Clinical Trials for COVID-19 (AAC ed.)
Mythbusting in Susceptibility Testing (JCM ed.)
Antimalarial Drug-Resistance (AAC ed.)
Staphylococcus argenteus: another coagulase positive Staphylococcus (JCM ed.)
β-lactam/β-lactamase inhibitor combinations (AAC ed.)
Reconciling Genotypic and Phenotypic Susceptibility Tests (JCM ed.)
Gaps in Laboratory Diagnosis of Fungal Diseases (JCM ed.)
Pandemic Built Environment (mSystems ed.)
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